doi:

DOI: 10.3724/SP.J.1260.2013.30137

Aata Biophysica Sinica (生物物理学报) 2013/29:12 PP.911-918

Crosstalk between Autophagy and Apoptosis in Endoplasmic Reticulum during Atherosclerosis


Abstract:
Autophagy is a reparative, life-sustaining process. During the process, cytoplasmic components are wrapped in double-membrane autophagic vesicles and degraded after fusing with lysosome. While apoptosis is a form of cell death regulated by genetic intrinsic mechanism under a certain physiological or pathological situation. Previous studies have shown that autophagy and apoptosis are involved in atherosclerosis(AS) and AS related cells, but their relationship is still unclear. This paper mainly reviews the different functions of autophagy and apoptosis in AS, and briefly summarizes the relationship between autophagy and apoptosis via their crosstalk in endoplasmic reticulum.

Key words:Atherosclerosis,Apoptosis,Autophagy,Endoplasmic reticulum

ReleaseDate:2015-04-19 19:20:50



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