DOI: 10.3724/SP.J.1260.2013.30137

Aata Biophysica Sinica (生物物理学报) 2013/29:12 PP.911-918

Crosstalk between Autophagy and Apoptosis in Endoplasmic Reticulum during Atherosclerosis

Autophagy is a reparative, life-sustaining process. During the process, cytoplasmic components are wrapped in double-membrane autophagic vesicles and degraded after fusing with lysosome. While apoptosis is a form of cell death regulated by genetic intrinsic mechanism under a certain physiological or pathological situation. Previous studies have shown that autophagy and apoptosis are involved in atherosclerosis(AS) and AS related cells, but their relationship is still unclear. This paper mainly reviews the different functions of autophagy and apoptosis in AS, and briefly summarizes the relationship between autophagy and apoptosis via their crosstalk in endoplasmic reticulum.

Key words:Atherosclerosis,Apoptosis,Autophagy,Endoplasmic reticulum

ReleaseDate:2015-04-19 19:20:50

1. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature, 2011, 473(7347): 317~325

2. Haberzettl P, Hill BG. Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response. Redox Biol, 2013, 1(1): 56~64

3. Ozcan L. Endoplasmic reticulum stress in cardiometabolic disorders. Curr Atheroscler Rep, 2012, 14(5): 469~475

4. Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF. Autophagy links inflammasomes to atherosclerotic progression. Cell Metab, 2012, 15(4): 534~544

5. Bao M, Zhang Y, Zhou H. Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-κB pathway. J Ethnopharmacol, 2013, 146(2): 543~551

6. Xu H, Duan J, Wang W, Dai S, Wu Y, Sun R, Ren J. Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular signal-regulated kinase in vascular endothelial cells. J Hypertens, 2008, 26(5): 956~963

7. Zhang YL, Cao YJ, You SJ, Li RX, Liu HH, Liu CF. Protective effects of autophagy against oxidized LDL-induced injury in endothelial cells. Zhonghua Yi Xue Za Zhi, 2010, 90(39): 2792~2796

8. Xie Y, You SJ, Zhang YL, Han Q, Cao YJ, Xu XS, Yang YP, Li J, Liu CF. Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells. Mol Med Rep, 2011, 4(3): 459~464

9. Shafique E, Choy WC, Liu Y, Feng J, Cordeiro B, Lyra A, Arafah M, Yassin-Kassab A, Zanetti AV, Clements RT, Bianchi C, Benjamin LE, Sellke FW, Abid MR. Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK. Aging, 2013, 5(7): 515~530.

10. Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A, Hill BG. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem J, 2013, 451(3): 375~388

11. Hill BG, Haberzettl P, Ahmed Y, Srivastava S, Bhatnagar A. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem J, 2008, 410: 525~534

12. Xu K, Yang Y, Yan M, Zhan J, Fu X, Zheng X. Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells. J Lipid Res, 2010, 51(9): 2581~2590

13. Salabei JK, Hill BG. Implications of autophagy for vascular smooth muscle cell function and plasticity. Free Radic Biol Med, 2013. 84(5): 448~454

14. Singh R, Cuervo AM. Lipophagy: Connecting autophagy and lipid metabolism. Int J Cell Biol, 2012, 2012: 282041

15. Matsuzawa T, Kim BH, Shenoy AR, Kamitani S, Miyake M, Macmicking JD. IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway. J Immunol, 2012, 189(2): 813~818

16. Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab, 2012, 15(4): 545~553

17. Maiuri MC, Grassia G, Platt AM, Carnuccio R, Ialenti A, Maffia P. Macrophage autophagy in atherosclerosis. Mediators Inflamm, 2013, 2013: 584715. DOI:10.1155/2013/584715

18. Martinet W, De Meyer I, Verheye S, Schrijvers DM, Timmermans JP, De Meyer GR. Drug-induced macrophage autophagy in atherosclerosis: For better or worse?. Basic Res Cardiol, 2013, 108(1): 1~11

19. Arora M, Kaul D. Coronary atherosclerosis: Significance of autophagic armour. World J Cardiol, 2012, 4(9): 271~274

20. Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF. Autophagy links inflammasomes to atherosclerotic progression. Cell Metab, 2012, 15(4): 534~544

21. Mitra S, Goyal T, Mehta JL. Oxidized LDL, LOX-1 and atherosclerosis. Cardiovasc Drugs Ther, 2011, 25(5): 419~429

22. Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol, 2011, 13(3): 184~190

23. Greig FH, Kennedy S, Spickett CM. Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radic Biol Med, 2012, 52(2): 266~280

24. Billet S, Aguilar F, Baudry C, Clauser E. Role of angiotensin II AT1 receptor activation in cardiovascular diseases. Kidney Int, 2008, 74(11): 1379~1384

25. Rössig L, Hermann C, Haendeler J, Assmus B, Zeiher AM, Dimmeler S. Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apotosis. Basic Res Cardiol, 2002, 97(1): 1~8

26. Tan NY, Li JM, Stocker R, Khachigian LM. Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement. Circ Res, 2009, 105(5): 422~430

27. Yamamoto S, Yancey PG, Zuo Y, Ma LJ, Kaseda R, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arterioscler Thromb Vasc Biol, 2011, 31(12): 2856~2864

28. Scull CM, Tabas I. Mechanisms of ER stress-induced apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol, 2011, 31(12): 2792~2797

29. Seimon T, Tabas I. Mechanisms and consequences of macrophage apoptosis in atherosclerosis. J Lipid Res, 2009, 50(Suppl): S382~S387

30. Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab, 2010, 12(5): 467~482

31. Monaco C, Gregan SM, Navin TJ, Foxwell BM, Davies AH, Feldmann M. Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis. Circulation, 2009, 120(24): 2462~2469

32. Hetz C. The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol, 2012, 13(2): 89~102

33. Zhou AX, Tabas I. The UPR in atherosclerosis. Semin Immunopathol, 2013, 35(3): 321~332

34. Matsumoto H, Miyazaki S, Matsuyama S, Takeda M, Kawano M, Nakagawa H, Nishimura K, Matsuo S. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biol Open, 2013, 2(10):1084~1090

35. Verfaillie T, Salazar M, Velasco G, Agostinis P. Linking ER stress to autophagy: Potential implications for cancer therapy. Int J Cell Biol, 2010, 2010: 930509. DOI:1155/2010/930509

36. Ishida Y, Nagata K. Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress. Autophagy, 2009, 5(8): 1217~1219

37. He C, Zhu H, Zhang W, Okon I, Wang Q, Li H, Le YZ, Xie Z. 7-ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. Am J Pathol, 2013, 183(2): 626~637

38. Zhou F, Yang Y, Xing D. Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J, 2011, 278(3): 403~413

39. Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, Xiang D, Ji M, Lawrence TS, Xu L. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ, 2010, 18(1): 60~71

40. Zhaorigetu S, Yang Z, Toma I, McCaffrey TA, Hu CA. Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem, 2011, 286(31): 27389~27398

41. Mahmood DF, Jguirim-Souissi I, Khadija El-H, Blondeau N, Diderot V, Amrani S, Slimane MN, Syrovets T, Simmet T, Rouis M. Peroxisome proliferator-activated receptor γ induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L: Potential role in atherosclerosis. J Biol Chem, 2011, 286(33): 28858~28866

42. Djavaheri-Mergny M, Maiuri MC, Kroemer G. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene, 2010, 29(12): 1717~1719

43. Williams JA, Hou Y, Ni HM, Ding WX. Role of Intracellular calcium in proteasome inhibitor-Induced endoplasmic reticulum stress, autophagy, and cell death. Pharm Res, 2013, 30(9): 2279~2289

44. Vicencio JM, Ortiz C, Criollo A, Jones AW, Kepp O, Galluzzi L, Joza N, Vitale I, Morselli E, Tailler M, Castedo M, Maiuri MC, Molgó J, Szabadkai G, Lavandero S, Kroemer G. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ, 2009, 16(7): 1006~1017

45. Smaili SS, Pereira GJ, Costa MM, Rocha KK, Rodrigues L, do Carmo LG, Hirata H, Hsu YT. The role of calcium stores in apoptosis and autophagy. Curr Mol Med, 2013, 13(2): 252~265

46. Muller C, Salvayre R, Nègre-Salvayre A, Vindis C. HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs. Cell Death Differ, 2010, 18(5): 817~828

47. Timmins JM, Ozcan L, Seimon TA, Li G, Malagelada C, Backs J, Backs T, Bassel-Duby R, Olson EN, Anderson ME, Tabas I. Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest, 2009, 119(10): 2925~2941