DOI: 10.3724/SP.J.1008.2011.00795

Academic Journal of Second Military Medical University (第二军医大学学报) 2011/31:7 PP.795-798

Effect of estrogen and its receptors on glutamate-induced neural cell injury

It has been proven that glutamate-induced excitatory toxicity can bring damage to nerve cells. Previous studies indicate that glutamate excitotoxicity-associated neuron damage play an important role in the pathogenesis of a number of nervous system diseases, and estrogen can protect neurons from glutamate excitotoxicity-associated neuron damage, which may be mediated by estrogen receptor. This paper reviews the latest progress regarding the protective effects of estrogen and its receptors against glutamate-induced neuron damage.

Key words:estrogens,estrogen receptors,glutamic acid,neural cell damage

ReleaseDate:2014-07-21 15:59:28

Funds:Key Program of Science and Technology Department of Guizhou Province(Qiankehe sy[2009]3054) and Governor’s Special Fund for Outstanding Scientific and Technology Education Talents of Guizhou Province(Qianshengzhuanhezi[2010] 86)

[1] Mattson M P.Glutamate and neurotrophic factors in neuronal plasticity and disease[J].Ann N Y Acad Sci,2008,1144:97-112.

[2] Liu P,Smith P F,Darlington C L.Glutamate receptor subunits expression in memory-associated brain structures:regional variations and effects of aging[J].Synapse,2008,62:834-841.

[3] Lee M C,Ting K K,Adams S,Brew B J,Chung R,Guillemin G J.Characterisation of the expression of NMDA receptors in human astrocytes[J].PloS One,2010,5:e14123.

[4] Cauli O,López-Larrubia P,Rodrigues T B,Cerdan S,Felipo V.Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain.Role of NMDA receptors[J].J Neurochem,2007,103:1334-1343.

[5] Klin Y,Zlotnik A,Boyko M,Ohayon S,Shapira Y,Teichberg V I.Distribution of radiolabeled L-glutamate and D-aspartate from blood into peripheral tissues in naive rats:significance for brain neuroprotection[J].Biochem Biophys Res Commun,2010,399:694-698.

[6] Cavus I,Pan J W,Hetherington H P,Abi-Saab W,Zaveri H P,Vives K P,et al.Decreased hippocampal volume on MRI is associated with increased extracelluar glutamate in epilepsy patients[J].Epilepsia,2008,49:1358-1366.

[7] Fernandes H B,Baimbridge K G,Church J,Hayden M R,Raymond L A.Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington’s disease[J].J Neurosci,2007,27:13614-13623.

[8] Singer H S,Morris C,Grados M.Glutamatergic modulatory therapy for Tourette syndrome[J].Med Hypotheses,2010,74:862-867.

[9] Zhang W,Miao Y,Zhou S,Wang B,Luo Q,Qiu Y.Involvement of glutamate transportant-1 in neuroprotection anginst global brain ischemia reperfusion injury induced by postconditioning in rats[J].Int J Mol Sci,2010,11:4407-4416.

[10] Fontainhas A M,Wang M,Liang K J,Chen S,Mettu P,Damani M,et al.Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission[J].PloS One,2011,6:e15973.

[11] Jover-Mengual T,Zukin R S,Etgen A M.MAPK signaling is critical to estradiol protection of CAI neurons in global ischemia[J].Endocrinology,2007,148:1131-1143.

[12] Sribnick E A,Ray S K,Banik N L.Estrogen prevents glutamate-induced apoptosis in C6 glioma cells by a receptor-mediated mechanism[J].Neuroscience,2006,137:197-209.

[13] Richeri A,Bianchimano P,Crutcher K A,Brauer M M.Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen[J].Cell Tissue,2010,340:287-301.

[14] Dominguez R,Micevych P.Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons[J].J Neurosci,2010,30:12589-12596.

[15] Watson C S,Alyea R A,Cunningham K A,Jeng Y J.Estrogens of multiple classes and their role in mental health disease mechanisms[J].Int J Womens Health,2010,9:153-166.

[16] Sarkaki A,Amani R,Badavi M,Moghaddam A Z,Aligholi H,Safahani M,et al.Pre-treatment effect of different doses of soy isoflavones on spatial learning and memory in an ovariectomized animal model of Alzheimer’s disease [J].Pak J Biol Sci,2008,11:1114-1119.

[17] Morissette M,Le Saux M,D’Astous M,Jourdain S,AI Sweidi S,Morin N,et al.Contribution of estrogen receptors α and β to the effects of estradiol in the brain[J].J Steroid Biochem Mol Biol,2008,108(3-5):327-338.

[18] Leung Y K,Mark P,Hassan S,Ho S M.Estrogen receptor (ER)-beta isoforms:a key to understanding ER-beta signaling [J].Proc Natl Acad Sci USA,2006,103:13162-13167.

[19] Jeng Y J,Kochukov M Y,Watson C S.Membrane estrogen receptor-α-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells[J].J Mol Signal,2009,4:2.

[20] Kuo J,Hamid N,Bondar G,Prossnitz E R,Micevych P.Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes[J].J Neurosci,2010,30:12950-12957.

[21] Fan X,Xu H,Warner M,Gustafsson J A.ERbeta in CNS:new roles in development and function[J].Prog Brain Res,2010,181:233-250.

[22] 王玉霞,鲁亚平,雌激素受体与神经系统疾病[J].生物学杂志,2010,27:79-80.

[23] Chaban V V,Mayer E A,Ennnes H S,Micevych P E.Estradiol inhibits ATP-induced intracellular calcium concentration increase in dorsal root ganglia neurons[J].Neuroscience,2003,118:941-948.

[24] Hilton G D,Nunez J L,Bambrick L,Thompson S M,McCarthy M M.Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is miediated by mGluR-induced release of Ca2+ from intracellular stores and is prevented by estradiol[J].Eur J Neurosci,2006,24:3008-3016.

[25] Sribnick E A,Del Re A M,Ray S K,Woodward J J,Banik N L.Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ infux through L-type voltage-gated Ca2+ channels[J].Brain Res,2009,1276:159-170.

[26] Schreihofer D A,Redmond L.Soy phytoestrogens are neuroprotective against stroke-like injury in vitro[J].Neuroscience,2009,158:602-609.

[27] Huang Y,Huang Y L,Lai B,Zheng P,Zhu Y C,Yao T.Raloxifene acutely reduces glutamate-induced intracellular calcium increase in cultured rat cortical neurons via inhibition of high-voltage-activated calcium current[J].Neuroscience,2007,47:334-341.

[28] Occhiuto F,Zangla G,Samperi S,Palumbo D R,Pino A,De Pasquale R,et al.The phytoestrogenic isoflavones from Trifolium pratense L.(Red clover) protects human cortical neurons from glutamate toxicity [J].Phytomedicine,2008,15:676-682.

[29] Jelks K B,Wylie R,Floyd C L,McAllister A K,Wise P.Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons:critical role of estrogen receptor-alpha[J].J Neurosci,2007,27:6903-6913.

[30] Xia Y,Xing J Z,Krukoff T L.Neuroprotective effects of R,R-tetrahydrochrysene against glutamate-induced cell death through anti-excitotoxic and antioxidant actions involving estrogen receptor-dependent and -independent pathways[J].Neuroscience,2009,162:292-306.

[31] Bryant D N,Dorsa D M.Roles of estrogen receptors alpha and beta in sexually dimorphic neuroprotection anainst glutamate toxicity[J].Neuroscience,2010,170:1261-1269.