doi:

DOI: 10.3724/SP.J.1008.2011.00795

Academic Journal of Second Military Medical University (第二军医大学学报) 2011/31:7 PP.795-798

Effect of estrogen and its receptors on glutamate-induced neural cell injury


Abstract:
It has been proven that glutamate-induced excitatory toxicity can bring damage to nerve cells. Previous studies indicate that glutamate excitotoxicity-associated neuron damage play an important role in the pathogenesis of a number of nervous system diseases, and estrogen can protect neurons from glutamate excitotoxicity-associated neuron damage, which may be mediated by estrogen receptor. This paper reviews the latest progress regarding the protective effects of estrogen and its receptors against glutamate-induced neuron damage.

Key words:estrogens,estrogen receptors,glutamic acid,neural cell damage

ReleaseDate:2014-07-21 15:59:28

Funds:Key Program of Science and Technology Department of Guizhou Province(Qiankehe sy[2009]3054) and Governor’s Special Fund for Outstanding Scientific and Technology Education Talents of Guizhou Province(Qianshengzhuanhezi[2010] 86)



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