DOI: 10.3724/SP.J.1008.2011.01310

Academic Journal of Second Military Medical University (第二军医大学学报) 2011/31:12 PP.1310-1315

Relationship of kallikrein 3 and vitamin D receptor polymorphisms and environmental factors with prostate cancer predisposition

Objective To investigate the relationship of the single nucleotide polymorphisms(SNPs) of kallikrein 3(KLK3) and vitamin D receptor (VDR) and environmental factors with prostate cancer predisposition in Chinese. Methods The genotypes of KLK3(rs2735839 is located between KLK2 and KLK3) and VDR (rs731236 is located exon 9) were determined by TaqMan/MGB Probe technology in 108 prostate cancer (PCa) patients and 242 community-based normal controls. The demographic information, body mass index(BMI), smoking, alcohol consumption, tea drinking, sport activity and other environmental factors were collected for the two groups. Univariate and multivariate logistic regression models were used to assess the relationship of genetic polymorphisms and environmental risk factors with PCa. Results The frequencies of SNPs rs2735839 (A/G) for KLK3 AA, AG and GG genotypes were 13.89%, 62.96% and 23.15% in PCa patients and 37.19%, 44.63%, 18.18% in controls, respectively, with significant difference found between the two groups(P=0.00). The frequencies of SNPs rs731236 (T/C) for VDR TT,TC and CC genotypes were 88.89%, 9,26%, 1.85% in PCa patients and 90.50%, 9.10%, 0.40% in controls, respectively, with no significant difference between the two groups. The study also showed that the risk for PCa in tea drinkers was only 0.58 fold that of non-tea drinkers (OR=0.58,95%CI,0.35-0.96). Conclusion Our study indicates that tea drinking is associated with the development of PCa; tea drinking is a protective factor against PCa; SNPs rs2735839 of KLK3 is significantly correlated with PCa; moreover, there is a multiplicative interaction between SNPs rs2735839 of KLK3 and environment factors. SNPs rs731236 of VDR is not correlated with PCa.

Key words:prostatic neoplasms,singal nucleotide polymorphism,environment,risk factors,tea

ReleaseDate:2014-07-21 16:05:33

Funds:National Natural Science Foundation of China (81072377)

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