DOI: 10.3724/SP.J.1004.2013.01969

Acta Automatica Sinica (自动化学报) 2013/39:12 PP.1969-1979

Control of Genetic Regulatory Networks: Opportunities and Challenges

It is well known that genetic regulatory networks (GRNs) are fundamental and important biological networks. This paper briefly reviews the main research progresses in the control of GRNs. Moreover, this paper proposes some fundamental scientific problems for the control of GRNs. In fact, life sciences and control theory are the real-world background and theoretical basis for the control of GRNs, respectively. Over the last few decades, the basic idea and methods of control theory have gradually infiltrated into the research of GRNs. At the same time, some control problems from life sciences also provide new opportunities and challenges for control science. The control of GRNs guides some potential routes to resolve the long-time perplexing problems in life sciences, such as the prolonging of lifespan, curing cancer and diabetes. Furthermore, the control of GRNs has potential real-world applications for the rapid developments of synthetic biology, networked medicine and personalized medicine.

Key words:Systems biology, genetic regulatory network (GRN), noise, positive feedback, negative feedback

ReleaseDate:2014-07-21 17:04:33

Funds:National Natural Science Foundation of China (61304151, 61025017, 11072254, 11105040) and Scientific Research Foundation of Henan University (2012YBZR007)