doi:

DOI: 10.3724/SP.J.1105.2011.11170

Acta Polymerica Sinica (高分子学报) 2011/011:9 PP.1020-1025

DESIGN OF GLUTATHIONE PEROXIDASE MIMICS BASED ON PROTEIN SCAFFOLDS


Abstract:
Selenium (Se),known as an essential trace elements,is closely related to human health and diseases.This essential trace element exists in at least 25 selenoproteins in the form of selenocysteine residue,which performs a variety of biological functions.Among these selenoproteins,glutathione peroxidase (GPx) is a well-known antioxidase,since it catalyzes the reduction of harmful peroxide by glutathione and protects cells against oxidative damage.Herein,some strategies and methods are presented to construct GPx mimics based on protein scaffolds.Through these studies,we expect to gain better understanding of the biological properties of selenoprotein,and even develop more effective approaches to create new selenoprotein mimics.

Key words:Selenium (Se), Selenocysteine, Glutathione peroxidase (GPx)

ReleaseDate:2014-07-21 15:55:28



1 Mills G C. J Biol Chem,1957,229:189~197

2 Porter D J.J Biol Chem,1980,255:7362~7370

3 Gibson Q H,Swoboda B E,Massey V.J Biol Chem,1964,239:3927~3934

4 Davis R L,Lavine C L,Arredondo M A.Int J Exp Diabetes Res,2002,3(3):185~192

5 Burke M P,Opeskin K.Med Sci Law,2002,42(1):10~13

6 Forgione M A,Cap A,Liao R.Circulation,2002,106(9):1154~1158

7 Power J H,Blumbergs P C.Acta Neuropathol,2009,117(1):63~73

8 Tramontano A,Janda K D,Lemer R A.Science,1986,234:1566~1570

9 Pauling L.Am Sci,1948,36:51~58

10 Luo G M,Zhu Z Q,Ding L.Biochem Biophys Res Commun,1994,198:1240~1247

11 Ding Lan(丁兰),Zhao Daqing(赵大庆),Liu Zi(刘仔),Luo Guimin(罗贵民).Science China Life Sciences(Science in China Series C)(中国科学C辑:生命科学),1998,28:108~114

12 Su D,Ren X J,You D L,Mu Y,Yan G L,Zhang Y,Luo G M,Xue Y,Shen J C.Arch Biochem Biophys,2001,395:177~184

13 Shi Chengbo(时成波),Liu Junqiu(刘俊秋),Luo Guimin(罗贵民).Chemical Journal of Chinese Universities(高等学校化学学报),2000,21:566~569

14 Ren X J,Gao S J,You D L.Biochem J,2001,359:369~374

15 Xu J J,Song J,Su J M,Wei J Y.J Mol Recognit,2010,23:352~359

16 Qi Xiaojie(齐小杰),Wang Lin(王琳),Fang Fang(方芳).Chemical Journal of Chinese Universities(高等学校化学学报),2001,22:1976~1978

17 Huo R,Wei J Y,Xu J J.J Mol Recognit,2008,21:323~328

18 Polgar L,Bender M L.J Am Chem Soc,1996,88:3153~3154

19 Polgar L,Bender M L.Biochemistry,1967,6:610~620

20 Neet K E,Koshland D E Jr.Proc Natl Acad Sci,USA,1966,56:1606~1611

21 Yokosawa H,Ojima S,Ishii S.J Biochem,1997,82:869~876

22 Wu Z P,Hilvert D.J Am Chem Soc,1990,112:5648~5649

23 Bell I M,Fisher M L,Wu Z P,Hilvert D.Biochemistry,1993,32:3754~3762

24 Liu J Q,Jiang M S,Luo G M,Yan G L,Shen J C.Biotechnol Lett,1998,20:693~696

25 Ren X J,Jemth P,Board P G,Luo G M,Mannervik B,Liu J Q,Zhang K,Shen J C.Chem Biol,2002,9; 789~794

26 Zheng K Y,Board P G,Fei X F,Sun Y,Lv S W,Yan G L,Liu J Q,Shen J C,Luo G M.Int J Biochem Cell Biol,2008,40:2090~2097

27 Turner N W,Jeans C W,Brain K R,Allender C J,Hlady V,Britt D W.Biotechnol Prog,2006,22:1474~1489

28 Wulff G.Chem Rev,2002,102:1~28

29 Murakami Y,Kikuchi J I,Hisaeda Y,Hayashida O.Chem Rev,1996,96:721~758

30 Wulff G.Angew.Chem Int Ed Engl,1995,34:1812~1832

31 Liu J Q,Luo G M,Gao S J,Zhang K,Chen X F,Shen J C.Chem Commun,1999,199~200

32 Liu L,Mao S Z,Liu X M,Huang X,Xu J Y,Liu J Q,Luo G M,Shen J C.Biomacromolecules,2008,9:363~368

33 Muller S,Senn H,Gsell B,Vetter W,Baron C,Bock A.Biochemistry,1994,33,3404~3412

34 Cowie D B,Cohen G N.Biochim Biophys Acta,1957,26,252~261

35 Budisa N,Steipe B,Demange P,Eckerskorn C,Kellermann S,Huber R.Eur J Biochem,1995,230:788~796

36 Budisa N,Minks C,Medrano F J,Lutz J,Huber R,Moroder L.Proc Natl Acad Sci,USA,1998,95:455~459

37 Yu H J,Liu J Q,B?ck A,Li J,Luo G M,Shen J C.J Biol Chem,2005,280:11930~11935

38 Ge Y,Qi Z H,Wang Y,Liu X M,Li J,Xu J Y,Liu J Q,Shen J C.Int J Biochem Cell Biol,2009, 41:900~906