DOI: 10.3724/SP.J.1041.2008.01051

Acta Psychologica Sinica (心理学报) 2008/40:10 PP.1051-1061

Genetics of Learning Abilities and Disabilities: Recent Developments from the UK and Possible Directions for Research in

It is exciting to witness the birth of behavioral genetics in China at a time when the field of genetics is exploding with new discoveries. We begin by discussing the potential for Chinese researchers to sidestep the false starts of previous genetic research on behavior and to become leaders rather than followers in behavioral genetics research. Using learning abilities and disabilities as an example, the rest of the paper considers ways in which quantitative genetic research can go beyond the nature versus nurture question to ask more interesting questions about genetics and psychology. These include the relationship between the normal and abnormal, longitudinal analyses of stability and change, and multivariate analyses of heterogeneity and homogeneity. The most important way to go beyond the rudimentary question about nature versus nurture is to identify the genes responsible for genetic influence on behavior. We briefly describe our quantitative genetic findings and genome-wide association studies of learning ability from the UK Twins Early Development Study (TEDS). It seems a safe prediction that the fast pace of genetic discoveries will continue and will increasingly affect the field of psychology in China and the rest of the world.

Key words:quantitative behavior genetics,molecular behavior genetics,future development in China

ReleaseDate:2014-07-21 14:28:11

Asbury, K., Almeida, D., Hibel, J., Harlaar, N., & Plomin, R. (submitted). Clones in the classroom: a daily diary study of the nonshared environmental (NSE) relationship between MZ differences in school experience and MZ differences in school achievement.

Butcher, L. M., Davis, O. S. P., Craig, I. W., & Plomin, R. (2007). Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes, Brain and Behavior, 7, 435-446.

Butcher, L. M., Meaburn, E., Liu, L., Hill, L., Al-Chalabi, A., Plomin, R. et al. (2004). Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits. Behavior Genetics, 34, 549-55.

Byrne, B., Samuelsson, S., Wadsworth, S., Hulslander, J., Corley, R., DeFries, J. C. et al. (2007). Longitudinal twin study of early literacy development: preschool through Grade 1. Reading and Writing, 20, 77-102.

Harlaar, N., Butcher, L. Meaburn, E., Craig, I.W. & Plomin, R. (2005). A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds. Journal of Child Psychology and Psychiatry, 46, 1097-1107.

Harlaar, N., Dale, P. S., & Plomin, R. (2007). From learning to read to reading to learn: substantial and stable genetic influence. Child Development, 78, 116-131.

Keenan, J. M., Betjemann, R., Wadsworth, S. J., DeFries, J. C., & Olson, R. K. (2006). Genetic and environmental influences on reading and listening comprehension. Journal of Research in Reading, 29, 75-91.

Kovas, Y., Haworth, C. M. A., Dale, P.S., & Plomin, R. (2007). The genetic and environmental origins of learning abilities and disabilities in the early school years. Monographs of the Society for Research in Child Development, 72, 1-144.

Kovas, Y. & Plomin, R. (2006). Generalist genes: implications for the cognitive sciences. Trends in Cognitive Sciences, 10, 198-203.

Martin, N. G. & Eaves, L. J. (1977). The genetical analysis of covariance structure. Heredity, 38, 79-95.

Meaburn, E. L., Harlaar, N., Craig, I. W., Schalkwyk, L. C., & Plomin, R. (2008). Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Molecular Psychiatry, 13, 729-740.

Oliver, B. & Plomin, R. (2007). Twins Early Development Study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behaviour problems from childhood through adolescence. Twin Research and Human Genetics, 10, 96-105.

Olson, R. K. (2007). Introduction to the special issue on genes, environment and reading. Reading and Writing, 20, 1-11.

Petrill, S. A., Deater-Deckard, K., Thompson, L. A., Schatschneider, C., DeThorne, L. S & Vandenbergh, D.J. (2007)

Longitudinal genetic analysis of early reading: The Western Reserve Reading Project. Reading & Writing, 20, 127-146

Plomin, R., Asbury, K., & Dunn, J. (2001). Why are children in the same family so different? Nonshared environment a decade later. Canadian Journal of Psychiatry, 46, 225-233.

Plomin, R. & Davis, O. S. P. (in press). The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA. Journal of Child Psychology and Psychiatry.

Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics. (5th ed.). New York: Worth Publishers. Plomin, R. & Kovas, Y. (2005). Generalist genes and learning disabilities. Psychological Bulletin, 131, 592-617.

Plomin, R., Kovas, Y., & Haworth, C. M. A. (2007). Genetic links between brain, mind and education. Mind, Brain and Education, 1, 11-19.

Plomin, R., Owen, M. J., & McGuffin, P. (1994). The genetic basis of complex human behaviors. Science, 264, 1733-1739.

Plomin, R. & Schalkwyk, L. C. (2007). Microarrays. Developmental Science, 10, 19-23.

Plomin, R. & Walker, S. O. (2003). Genetics and educational psychology. British Journal of Educational Psychology, 73, 3-14.

Samuelsson, S., Olson, R.K., Wadsworth, S., Corley, R., DeFries, J.C., Wilcutt, E. et al. (2007). Genetic and environmental influences on prereading skills and early reading and spelling development in the United States, Australia, and Scandinavia. Reading and Writing, 20, 51-75.

Thompson, L. A., Detterman, D. K., & Plomin, R. (1991). Associations between cognitive abilities and scholastic achievement: genetic overlap but environmental differences. Psychological Science, 2, 158-165.

Turkheimer, E. & Waldron, M. (2000). Nonshared environment: a theoretical, methodological, and quantitative review. Psychological Bulletin, 126, 78-108.

Walker, S. O. & Plomin, R. (2005). The nature - nurture question: teachers' perceptions of how genes and the environment influence educationally relevant behavior. Educational Psychology, 25, 509-5.

Wellcome Trust Case Control Consortium (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661-678.