DOI: 10.3724/SP.J.1042.2016.00159

Advances in Psychological Science (心理科学进展) 2016/24:2 PP.159-172

The neural mechanisms of impulsivity implicated in drug addiction and non-drug addiction

Mounting evidence has demonstrated that impulsivity could be a potential biomarker that plays a crucial role in the development of addictive behaviors, thus impulsivity is considered a possible treatment target for early intervention of addiction. Nevertheless, it remains unclear how the mechanisms underlying the trajectories of impulsivity are involved in drug addiction and non-drug addiction. This project aims to identify the neural mechanisms of impulsivity in both nicotine dependence and internet gaming disorder by combining a direct comparison of drug and non-drug addictive behaviors with longitudinal studies and a cognitive-behavioral intervention study, using neurocognitive tasks and neuroimaging techniques. Firstly, nicotine-dependent individuals and internet gaming addicts would be tested on a series of behavioral tasks of impulsivity as well as in fronto-striatal brain systems using both structured and functional magnetic resonance imaging (fMRI) with a 3T Philips Trio MRI. Then we will move on to investigate the predictive role of impulsivity for nicotine dependence and internet gaming disorder through a 2 to 3 year follow-up study with a large sample of non-addicted adolescents consisting of two groups with either high- or low- levels of impulsivity. Thirdly, a study of 6 to 12 month cognitive behavioral intervention would be conducted on nicotine-dependent individuals and internet gaming addicts to explore the possible effects of reducing impulsivity level on the exacerbation of addictive behaviors. And this study will also evaluate the effects of continuous behavioral training on brain functions in fronto-striatal brain systems through fMRI tests. Totally, these studies should be helpful for shedding light on the possible efficacy of impulsivity as a potential biomarker and treatment target for addictive disorders.

Key words:addiction,impulsivity,inhibitory control,nicotine dependence,internet gaming disorder

ReleaseDate:2016-12-19 16:07:47

李琦, 齐玥, 田莫千, 张侃, 刘勋. (2015). 网络成瘾者奖赏系统和认知控制系统的神经机制. 生物化学与生物物理进展, 42(1), 32-40.

伍志刚, 苏中华, 郝伟. (2004). 中国五地区酒依赖者社会人口学特征及相关因素分析. 中国行为医学科学, 13(1), 52-54.

Agrawal, A., Jacobson, K. C., Prescott, C. A., & Kendler, K. S. (2004). A twin study of personality and illicit drug use and abuse/dependence. Twin Research, 7(1), 72-81.

Albein-Urios, N., Martinez-González, J. M., Lozano, Ó., Clark, L., & Verdejo-García, A. (2012). Comparison of impulsivity and working memory in cocaine addiction and pathological gambling: Implications for cocaine-induced neurotoxicity. Drug and Alcohol Dependence, 126(1-2), 1-6.

Audrain-McGovern, J., Rodriguez, D., Epstein, L. H., Cuevas, J., Rodgers, K., & Wileyto, E. P. (2009). Does delay discounting play an etiological role in smoking or is it a consequence of smoking?. Drug and Alcohol Dependence, 103(3), 99-106.

Balodis, I. M., Kober, H., Worhunsky, P. D., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2012). Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biological Psychiatry, 71(8), 749-757.

Bari, A., Mar, A. C., Theobald, D. E., Elands, S. A., Oganya, K. C. N. A., Eagle, D. M., & Robbins, T. W. (2011). Prefrontal and monoaminergic contributions to stop-signal task performance in rats. The Journal of Neuroscience, 31(25), 9254-9263.

Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nature Neuroscience, 8(11), 1458-1463.

Bechara, A., Tranel, D., & Damasio, H. (2000). Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain, 123(11), 2189-2202.

Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science, 320(5881), 1352-1355.

Bickel, W. K., Jarmolowicz, D. P., Mueller, E. T., Koffarnus, M. N., & Gatchalian, K. M. (2012). Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence. Pharmacology & Therapeutics, 134(3), 287-297.

Bickel, W. K., Yi, R., Landes, R. D., Hill, P. F., & Baxter, C. (2011). Remember the future: Working memory training decreases delay discounting among stimulant addicts. Biological Psychiatry, 69(3), 260-265.

Bjork, J. M., Hommer, D. W., Grant, S. J., & Danube, C. (2004). Impulsivity in abstinent alcohol-dependent patients: Relation to control subjects and type 1-/type 2-like traits. Alcohol, 34(2-3), 133-150.

Bobova, L., Finn, P. R., Rickert, M. E., & Lucas, J. (2009). Disinhibitory psychopathology and delay discounting in alcohol dependence: Personality and cognitive correlates. Experimental and Clinical Psychopharmacology, 17(1), 51-61.

Bradford, W. D. (2010). The association between individual time preferences and health maintenance habits. Medical Decision Making, 30(1), 99-112.

Butler, G. K. L., & Montgomery, A. M. J. (2004). Impulsivity, risk taking and recreational ‘ecstasy’ (MDMA) use. Drug and Alcohol Dependence, 76(1), 55-62.

Cao, F. L., Su, L. Y., Liu, T. Q., & Gao, X. P. (2007). The relationship between impulsivity and Internet addiction in a sample of Chinese adolescents. European Psychiatry, 22(7), 466-471.

Chamberlain, S. R., Müller, U., Robbins, T. W., & Sahakian, B. J. (2006). Neuropharmacological modulation of cognition. Current Opinion in Neurology, 19(6), 607-612.

Cheng, J. Q., Lu, Y. H., Han, X. D., González-Vallejo, C., & Sui, N. (2012). Temporal discounting in heroin-dependent patients: No sign effect, weaker magnitude effect, and the relationship with inhibitory control. Experimental and Clinical Psychopharmacology, 20(5), 400-409.

Choi, J. S., Park, S. M., Roh, M. S., Lee, J. Y., Park, C. B., Hwang, J. Y., ... Jung, H. Y. (2014). Dysfunctional inhibitory control and impulsivity in Internet addiction. Psychiatry Research, 215(2), 424-428.

Clark, L., & Limbrick-Oldfield, E. H. (2013). Disordered gambling: A behavioral addiction. Current Opinion in Neurobiology, 23(4), 655-659.

Coffey, S. F., Gudleski, G. D., Saladin, M. E., & Brady, K. T. (2003). Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals. Experimental and Clinical Psychopharmacology, 11(1), 18-25.

Courtney, K. E., Ghahremani, D. G., & Ray, L. A. (2013). Fronto-striatal functional connectivity during response inhibition in alcohol dependence. Addiction Biology, 18(3), 593-604.

Dalbudak, E., Evren, C., Aldemir, S., Coskun, K. S., Ugurlu, H., & Yildirim, F. G. (2013). Relationship of internet addiction severity with depression, anxiety, and alexithymia, temperament and character in university students. Cyberpsychology, Behavior, and Social Networking, 16(4), 272-278.

Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron, 69(4), 680-694.

Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., ... Robbins, T. W. (2007). Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science, 315(5816), 1267-1270.

de Wit, H. (2009). Impulsivity as a determinant and consequence of drug use: A review of underlying processes. Addiction Biology, 14(1), 22-31.

Deutsch, R., & Strack, F. (2006). Duality models in social psychology: From dual processes to interacting systems. Psychological Inquiry, 17(3), 166-172.

Dick, D. M., Smith, G., Olausson, P., Mitchell, S. H., Leeman, R. F., O'Malley, S. S., & Sher, K. (2010). Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addiction Biology, 15(2), 217-226.

Dong, G., DeVito, E. E., Du, X., & Cui, Z. (2012). Impaired inhibitory control in ‘internet addiction disorder’: A functional magnetic resonance imaging study. Psychiatry Research: Neuroimaging, 203(2-3), 153-158.

Economidou, D., Dalley, J. W., & Everitt, B. J. (2011). Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seeking. Biological Psychiatry, 69(3), 266-274.

Economidou, D., Pelloux, Y., Robbins, T. W., Dalley, J. W., & Everitt, B. J. (2009). High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence. Biological Psychiatry, 65(10), 851-856.

Ersche, K. D., Barnes, A., Jones, P. S., Morein-Zamir, S., Robbins, T. W., & Bullmore, E. T. (2011). Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence. Brain, 134(7), 2013-2024.

Ersche, K. D., Clark, L., London, M., Robbins, T. W., & Sahakian, B. J. (2006). Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology, 31(5), 1036-1047.

Ersche, K. D., Jones, P. S., Williams, G. B., Turton, A. J., Robbins, T. W., & Bullmore, E. T. (2012). Abnormal brain structure implicated in stimulant drug addiction. Science, 335(6068), 601-604.

Ersche, K. D., Jones, P. S., Williams, G. B., Smith, D. G., Bullmore, E. T., & Robbins, T. W. (2013). Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence. Biological Psychiatry, 74(2), 137-144.

Ersche, K. D., Turton, A. J., Pradhan, S., Bullmore, E. T., & Robbins, T. W. (2010). Drug addiction endophenotypes: Impulsive versus sensation-seeking personality traits. Biological Psychiatry, 68(8), 770-773.

Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology, 146(4), 348-361.

Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008). Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1507), 3125-3135.

Everitt, B. J., & Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: From actions to habits to compulsion. Nature Neuroscience, 8(11), 1481-1489.

Everitt, B. J., & Robbins, T. W. (2013). From the ventral to the dorsal striatum: Devolving views of their roles in drug addiction. Neuroscience & Biobehavioral Reviews, 37(9), 1946-1954.

Field, M., Christiansen, P., Cole, J., & Goudie, A. (2007). Delay discounting and the alcohol Stroop in heavy drinking adolescents. Addiction, 102(4), 579-586.

Fields, S., Leraas, K., Collins, C., & Reynolds, B. (2009). Delay discounting as a mediator of the relationship between perceived stress and cigarette smoking status in adolescents. Behavioural Pharmacology, 20(5-6), 455-460.

Fillmore, M. T., & Rush, C. R. (2002). Impaired inhibitory control of behavior in chronic cocaine users. Drug and Alcohol Dependence, 66(3), 265-273.

First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1995). Structured Clinical Interview for DSM-IV-Patient Edition (SCID-I/P, Version 2.0). Biometrics Research Department, New York State Psychiatric Institute: New York.

Fishbein, D. H., Krupitsky, E., Flannery, B. A., Langevin, D. J., Bobashev, G., Verbitskaya, E., ... Tsoy, M. (2007). Neurocognitive characterizations of Russian heroin addicts without a significant history of other drug use. Drug and Alcohol Dependence, 90(1), 25-38.

Fisoun, V., Floros, G., Siomos, K., Geroukalis, D., & Navridis, K. (2012). Internet addiction as an important predictor in early detection of adolescent drug use experience-implications for research and practice. Journal of Addiction Medicine, 6(1), 77-84.

Goldstein, R. Z., Tomasi, D., Rajaram, S., Cottone, L. A., Zhang, L., Maloney, T., ... Volkow, N. D. (2007). Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction. Neuroscience, 144(4), 1153-1159.

Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry, 159(10), 1642-1652.

Goudriaan, A. E., Grekin, E. R., & Sher, K. J. (2011). Decision making and response inhibition as predictors of heavy alcohol use: A prospective study. Alcoholism: Clinical and Experimental Research, 35(6), 1050-1057.

Goudriaan, A. E., Oosterlaan, J., De Beurs, E., & van Den Brink, W. (2006). Neurocognitive functions in pathological gambling: A comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101(4), 534-547.

Heatherton, T. F., Kozlowski, L. T., Frecker, R. C., & Fagerstrom, K. O. (1991). The Fagerström test for nicotine dependence: A revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction, 86(9), 1119-1127.

Heil, S. H., Johnson, M. W., Higgins, S. T., & Bickel, W. K. (2006). Delay discounting in currently using and currently abstinent cocaine-dependent outpatients and non-drug-using matched controls. Addictive Behaviors, 31(7), 1290-1294.

Hester, R., & Garavan, H. (2004). Executive dysfunction in cocaine addiction: Evidence for discordant frontal, cingulate, and cerebellar activity. The Journal of Neuroscience, 24(49), 11017-11022.

Heyman, G. M., & Gibb, S. P. (2006). Delay discounting in college cigarette chippers. Behavioural Pharmacology, 17(8), 669-679.

Hoffman, W. F., Moore, M., Templin, R., McFarland, B., Hitzemann, R. J., & Mitchell, S. H. (2006). Neuropsychological function and delay discounting in methamphetamine-dependent individuals. Psychopharmacology, 188(2), 162-170.

Hoffman, W. F., Schwartz, D. L., Huckans, M. S., McFarland, B. H., Meiri, G., Stevens, A. A., & Mitchell, S. H. (2008). Cortical activation during delay discounting in abstinent methamphetamine dependent individuals. Psychopharmacology, 201(2), 183-193.

Holden, C. (2010). Behavioral addictions debut in proposed DSM-V. Science, 327(5968), 935-935.

Jentsch, J. D., & Taylor, J. R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: Implications for the control of behavior by reward-related stimuli. Psychopharmacology, 146(4), 373-390.

Jones, B. A., Landes, R. D., Yi, R., & Bickel, W. K. (2009). Temporal horizon: Modulation by smoking status and gender. Drug and Alcohol Dependence, 104, S87-S93.

Kalivas, P. W., Volkow, N., & Seamans, J. (2005). Unmanageable motivation in addiction: A pathology in prefrontal-accumbens glutamate transmission. Neuron, 45(5), 647-650.

Kamarajan, C., Porjesz, B., Jones, K. A., Choi, K., Chorlian, D. B., Padmanabhapillai, A., ... Begleiter, H. (2005). Alcoholism is a disinhibitory disorder: Neurophysiological evidence from a Go/No-Go task. Biological Psychology, 69(3), 353-373.

Kaufman, J. N., Ross, T. J., Stein, E. A., & Garavan, H. (2003). Cingulate hypoactivity in cocaine users during a GO-NOGO task as revealed by event-related functional magnetic resonance imaging. The Journal of Neuroscience, 23(21), 7839-7843.

Kirby, K. N., & Petry, N. M. (2004). Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls. Addiction, 99(4), 461-471.

Kirby, K. N., Petry, N. M., & Bickel, W. K. (1999). Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. Journal of Experimental Psychology: General, 128(1), 78-87.

Ko, C. H., Liu, G. C., Yen, J. Y., Yen, C. F., Chen, C. S., & Lin, W. C. (2013). The brain activations for both cue-induced gaming urge and smoking craving among subjects comorbid with Internet gaming addiction and nicotine dependence. Journal of Psychiatric Research, 47(4), 486-493.

Ko, C. H., Yen, J. Y., Yen, C. F., Chen, C. S., & Chen, C. C. (2012). The association between Internet addiction and psychiatric disorder: A review of the literature. European Psychiatry, 27(1), 1-8.

Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8(11), 1450-1457.

Krishnan-Sarin, S., Duhig, A. M., McKee, S. A., McMahon, T. J., Liss, T., McFetridge, A., & Cavallo, D. A. (2006). Contingency management for smoking cessation in adolescent smokers. Experimental and Clinical Psychopharmacology, 14(3), 306-310.

Landes, R. D., Christensen, D. R., & Bickel, W. K. (2012). Delay discounting decreases in those completing treatment for opioid dependence. Experimental and Clinical Psychopharmacology, 20(4), 302-309.

Lawrence, A. J., Luty, J., Bogdan, N. A., Sahakian, B. J., & Clark, L. (2009a). Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals. Addiction, 104(6), 1006-1015.

Lawrence, A. J., Luty, J., Bogdan, N. A., Sahakian, B. J., & Clark, L. (2009b). Impulsivity and response inhibition in alcohol dependence and problem gambling. Psychopharmacology, 207(1), 163-172.

Lee, B., London, E. D., Poldrack, R. A., Farahi, J., Nacca, A., Monterosso, J. R., ... Mandelkern, M. A. (2009). Striatal dopamine D2/D3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. The Journal of Neuroscience, 29(47), 14734-14740.

Lee, G. P., Storr, C. L., Ialongo, N. S., & Martins, S. S. (2011). Compounded effect of early adolescence depressive symptoms and impulsivity on late adolescence gambling: A longitudinal study. Journal of Adolescent Health, 48(2), 164-169.

Lee, H. W., Choi, J. S., Shin, Y. C., Lee, J. Y., Jung, H. Y., & Kwon, J. S. (2012). Impulsivity in internet addiction: A comparison with pathological gambling. Cyberpsychology, Behavior, and Social Networking, 15(7), 373-377.

Lee, Y. S., Han, D. H., Kim, S. M., & Renshaw, P. F. (2013). Substance abuse precedes internet addiction. Addictive Behaviors, 38(4), 2022-2025.

Leeman, R. F., & Potenza, M. N. (2012). Similarities and differences between pathological gambling and substance use disorders: A focus on impulsivity and compulsivity. Psychopharmacology, 219(2), 469-490.

Leland, D. S., & Paulus, M. P. (2005). Increased risk-taking decision-making but not altered response to punishment in stimulant-using young adults. Drug and Alcohol Dependence, 78(1), 83-90.

Leshner, A. I. (1997). Addiction is a brain disease, and it matters. Science, 278(5335), 45-47.

Levin, F. R., Mariani, J. J., Secora, A., Brooks, D., Cheng, W. Y., Bisaga, A., ... Hennessy, G. (2009). Atomoxetine treatment for cocaine abuse and adult attention deficit/hyperactivity disorder (ADHD): A preliminary open trial. Journal of Dual Diagnosis, 5(1), 41-56.

Li, C. S. R., Milivojevic, V., Kemp, K., Hong, K., & Sinha, R. (2006). Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug and Alcohol Dependence, 85(3), 205-212.

Limbrick-Oldfield, E. H., van Holst, R. J., & Clark, L. (2013). Fronto-striatal dysregulation in drug addiction and pathological gambling: Consistent inconsistencies? NeuroImage: Clinical, 2, 385-393.

Logan, G. D., Schachar, R. J., & Tannock, R. (1997). Impulsivity and inhibitory control. Psychological Science, 8(1), 60-64.

Loo, J. M. Y., Raylu, N., & Oei, T. P. S. (2008). Gambling among the Chinese: A comprehensive review. Clinical Psychology Review, 28(7), 1152-1166.

MacKillop, J., Amlung, M. T., Few, L. R., Ray, L. A., Sweet, L. H., & Munafò, M. R. (2011). Delayed reward discounting and addictive behavior: A meta-analysis. Psychopharmacology, 216(3), 305-321.

MacKillop, J., Miranda, R., Jr., Monti, P. M., Ray, L. A., Murphy, J. G., Rohsenow, D. J., ... & Gwaltney, C. J. (2010). Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders. Journal of Abnormal Psychology, 119(1), 106-114.

MacLeod, C. M. (1991). Half a century of research on the Stroop effect: An integrative review. Psychological Bulletin, 109(2), 163-203.

Madden, G. J., Petry, N. M., Badger, G. J., & Bickel, W. K. (1997). Impulsive and self-control choices in opioid- dependent patients and non-drug-using control patients: Drug and monetary rewards. Experimental and Clinical Psychopharmacology, 5(3), 256-262.

McRae-Clark, A. L., Carter, R. E., Killeen, T. K., Carpenter, M. J., White, K. G., & Brady, K. T. (2010). A placebo-controlled trial of atomoxetine in marijuana-dependent individuals with attention deficit hyperactivity disorder. The American Journal on Addictions, 19(6), 481-489.

Mitchell, J. M., Fields, H. L., D'Esposito, M., & Boettiger, C. A. (2005). Impulsive responding in alcoholics. Alcoholism: Clinical and Experimental Research, 29(12), 2158-2169.

Mitchell, J. M., Tavares, V. C., Fields, H. L., D'Esposito, M., & Boettiger, C. A. (2007). Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls. Neuropsychopharmacology, 32(2), 439-449.

Moeller, F. G., Barratt, E. S., Fischer, C. J., Dougherty, D. M., Reilly, E. L., Mathias, C. W., & Swann, A. C. (2004). P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects. Neuropsychobiology, 50(2), 167-173.

Moffitt, T. E., Arseneault, L., Belsky, D., Dickson, N., Hancox, R. J., Harrington, H., ... Caspi, A. (2011). A gradient of childhood self-control predicts health, wealth, and public safety. Proceedings of the National Academy of Sciences of the United States of America, 108(7), 2693-2698.

Monterosso, J. R., Ainslie, G., Xu, J. S., Cordova, X., Domier, C. P., & London, E. D. (2007). Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting task. Human Brain Mapping, 28(5), 383-393.

Monterosso, J. R., Aron, A. R., Cordova, X., Xu, J. S., & London, E. D. (2005). Deficits in response inhibition associated with chronic methamphetamine abuse. Drug and Alcohol Dependence, 79(2), 273-277.

Nigg, J. T., Wong, M. M., Martel, M. M., Jester, J. M., Puttler, L. I., Glass, J. M., ... Zucker, R. A. (2006). Poor response inhibition as a predictor of problem drinking and illicit drug use in adolescents at risk for alcoholism and other substance use disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 45(4), 468-475.

Noël, X., Bechara, A., Dan, B., Hanak, C., & Verbanck, P. (2007). Response inhibition deficit is involved in poor decision making under risk in nonamnesic individuals with alcoholism. Neuropsychology, 21(6), 778-786.

O'Brien, C., Volkow, N., & Li, T. K. (2006). What's in a word? Addiction versus dependence in DSM-V. American Journal of Psychiatry, 163(5), 764-765.

Parrott, A. C., Sisk, E., & Turner, J. J. D. (2000). Psychobiological problems in heavy ‘ecstasy’ (MDMA) polydrug users. Drug and Alcohol Dependence, 60(1), 105-110.

Pattij, T., & De Vries, T. J. (2013). The role of impulsivity in relapse vulnerability. Current Opinion in Neurobiology, 23(4), 700-705.

Patton, J. H., Stanford, M. S., & Barratt, E.S. (1995). Factor structure of the Barratt impulsiveness scale. Journal of Clinical Psychology, 51(6), 768-774.

Perry, J. L., & Carroll, M. E. (2008). The role of impulsive behavior in drug abuse. Psychopharmacology, 200(1), 1-26.

Petry, N. M., & O'Brien, C. P. (2013). Internet gaming disorder and the DSM-5. Addiction, 108(7), 1186-1187.

Petry, N. M., Rehbein, F., Gentile, D. A., Lemmens, J. S., Rumpf, H.J., Mößle, T., … O'Brien, C. P. (2014). An international consensus for assessing internet gaming disorder using the new DSM-5 approach. Addiction, 109(9), 1399-1406.

Potenza, M. N. (2008). The neurobiology of pathological gambling and drug addiction: An overview and new findings. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1507), 3181-3189.

Potenza, M. N., & Taylor, J. R. (2009). Found in translation: Understanding impulsivity and related constructs through integrative preclinical and clinical research. Biological Psychiatry, 66(8), 714-716.

Reynolds, B., Leraas, K., Collins, C., & Melanko, S. (2009). Delay discounting by the children of smokers and nonsmokers. Drug and Alcohol Dependence, 99(1-3), 350-353.

Reynolds, B., Patak, M., Shroff, P., Penfold, R. B., Melanko, S., & Duhig, A. M. (2007). Laboratory and self-report assessments of impulsive behavior in adolescent daily smokers and nonsmokers. Experimental and Clinical Psychopharmacology, 15(3), 264-271.

Robbins, T. W., Ersche, K. D., & Everitt, B. J. (2008). Drug addiction and the memory systems of the brain. Annals of the New York Academy of Sciences, 1141(1), 1-21.

Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012). Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry. Trends in Cognitive Sciences, 16(1), 81-91.

Robinson, E. S., Eagle, D. M., Mar, A. C., Bari, A., Banerjee, G., Jiang, X. S., ... Robbins, T. W. (2008). Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat. Neuropsychopharmacology, 33(5), 1028-1037.

Rogers, R. D., Everitt, B. J., Baldacchino, A., Blackshaw, A. J., Swainson, R., Wynne, K., ... Robbins, T. W. (1999). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology, 20(4), 322-339.

Salo, R., Nordahl, T. E., Possin, K., Leamon, M., Gibson, D. R., Galloway, G. P., ... Sullivan, E. V. (2002). Preliminary evidence of reduced cognitive inhibition in methamphetamine- dependent individuals. Psychiatry Research, 111(1), 65-74.

Schoenbaum, G., & Shaham, Y. (2008). The role of orbitofrontal cortex in drug addiction: A review of preclinical studies. Biological Psychiatry, 63(3), 256-262.

Simon, S. L., Domier, C., Carnell, J., Brethen, P., Rawson, R., & Ling, W. (2000). Cognitive impairment in individuals currently using methamphetamine. The American Journal on Addictions, 9(3), 222-231.

Slutske, W. S., Moffitt, T. E., Poulton, R., & Caspi, A. (2012). Undercontrolled temperament at age 3 predicts disordered gambling at age 32: A Longitudinal Study of a Complete Birth Cohort. Psychological Science, 23(5), 510-516.

Spinella, M. (2002). Correlations between orbitofrontal dysfunction and tobacco smoking. Addiction Biology, 7(4), 381-384.

Stacy, A. W., & Wiers, R. W. (2010). Implicit cognition and addiction: A tool for explaining paradoxical behavior. Annual Review of Clinical Psychology, 6, 551-575.

Sweitzer, M. M., Donny, E. C., Dierker, L. C., Flory, J. D., & Manuck, S. B. (2008). Delay discounting and smoking: Association with the Fagerström Test for Nicotine Dependence but not cigarettes smoked per day. Nicotine & Tobacco Research, 10(10), 1571-1575.

Tao, R., Huang, X. Q., Wang, J., Zhang, H. M., Zhang, Y., & Li, M. C. (2010). Proposed diagnostic criteria for internet addiction. Addiction, 105(3), 556-564.

Tarter, R. E., Kirisci, L., Mezzich, A., Cornelius, J. R., Pajer, K., Vanyukov, M., ... Clark, D. (2003). Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. American Journal of Psychiatry, 160(6), 1078-1085.

Verdejo-García, A., Lawrence, A. J., & Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies. Neuroscience & Biobehavioral Reviews, 32(4), 777-810.

Verdejo-García, A., & Pérez-García, M. (2007). Profile of executive deficits in cocaine and heroin polysubstance users: Common and differential effects on separate executive components. Psychopharmacology, 190(4), 517-530.

Verdejo-García, A., Rivas-Pérez, C., Vilar-López, R., & Pérez- García, M. (2007). Strategic self-regulation, decision-making and emotion processing in poly-substance abusers in their first year of abstinence. Drug and Alcohol Dependence, 86(2-3), 139-146.

Vitaro, F., Arseneault, L., & Tremblay, R. E. (1997). Dispositional predictors of problem gambling in male adolescents. American Journal of Psychiatry, 154(12), 1769-1770.

Volkow, N. D., & Baler, R. D. (2012). To stop or not to stop? Science, 335(6068), 546-548.

Volkow, N. D., Chang, L. D., Wang, G. J., Fowler, J. S., Franceschi, D., Sedler, M. J., ... Logan, J. (2001). Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. American Journal of Psychiatry, 158(3), 383-389.

Walsh, S. L., Middleton, L. S., Wong, C. J., Nuzzo, P. A., Campbell, C. L., Rush, C. R., & Lofwall, M. R. (2013). Atomoxetine does not alter cocaine use in cocaine dependent individuals: A double blind randomized trial. Drug and Alcohol Dependence, 130(1-3), 150-157.

Wesley, M. J., & Bickel, W. K. (2014). Remember the future II: Meta-analyses and functional overlap of working memory and delay discounting. Biological Psychiatry, 75(6), 435-448.

Wexler, B. E. (2011). Computerized cognitive remediation treatment for substance abuse disorders. Biological Psychiatry, 69(3), 197-198.

Whiteside, S. P., & Lynam, D. R. (2003). Understanding the role of impulsivity and externalizing psychopathololgy in alcohol abuse: Application of the UPPS impulsive behavior scale. Experimental and Clinical Psychopharmacology, 11(3), 210-217.

Wiers, R. W., Eberl, C., Rinck, M., Becker, E. S., & Lindenmeyer, J. (2011). Retraining automatic action tendencies changes alcoholic patients' approach bias for alcohol and improves treatment outcome. Psychological Science, 22(4), 490-497.

Wilens, T. E., Adler, L. A., Weiss, M. D., Michelson, D., Ramsey, J. L., Moore, R. J., ... Levine, L. R. (2008). Atomoxetine treatment of adults with ADHD and comorbid alcohol use disorders. Drug and Alcohol Dependence, 96(1-2), 145-154.

Wilens, T. E., & Morrison, N. R. (2011). The intersection of attention-deficit/hyperactivity disorder and substance abuse. Current Opinion in Psychiatry, 24(4), 280-285.

Winstanley, C. A., Olausson, P., Taylor, J. R., & Jentsch, J. D. (2010). Insight into the relationship between impulsivity and substance abuse from studies using animal models. Alcoholism: Clinical and Experimental Research, 34(8), 1306-1318.

Wong, M. M., Nigg, J. T., Zucker, R. A., Puttler, L. I., Fitzgerald, H. E., Jester, J. M., ... Adams, K. (2006). Behavioral control and resiliency in the onset of alcohol and illicit drug use: A prospective study from preschool to adolescence. Child Development, 77(4), 1016-1033.

Yan, W. S., Li, Y. H., Xiao, L., Zhu, N., Bechara, A., & Sui, N. (2014). Working memory and affective decision-making in addiction: A neurocognitive comparison between heroin addicts, pathological gamblers and healthy controls. Drug and Alcohol Dependence, 134(1), 194-200.

Young, K. S. (1998). Internet addiction: The emergence of a new clinical disorder. CyberPsychology & Behavior, 1(3), 237-244.

Young, K. S. (2009). Internet addiction test. Retrieved July 28, 2009, from