DOI: 10.3724/SP.J.1042.2018.00488

Advances in Psychological Science (心理科学进展) 2018/26:3 PP.488-495

The early stages of Alzheimer's disease:Subjective cognitive impairment?

Subjective cognitive impairment (SCI) is referred to as a cognitive impairment complaints with no pathological aspects of objective evidence. In recent years it has become a hot topic of concern in the field of dementia research since researchers have found that SCI patients are more likely to suffer from AD, thus it is likely to be an earlier stage of AD and MCI. There are however, great differences in the prediction effect of SCI. This paper systematically reviews recent researches status of subjective cognitive impairment, including the concepts and measurement of subjective cognitive impairment, brain changes and bio-markers, and the relationship between SCI and AD and prospects for the future research.

Key words:subjective cognitive impairment,Alzheimer's disease,prediction

ReleaseDate:2018-03-29 16:57:02

赵静洁, 凌云, 王兴璇, 吴桂元, 李翠松. (2008). 综合护理对老年性痴呆认知功能障碍改善的临床观察. 护士进修杂志, 23(20), 1865-1866.

朱敏敏, 孙中武. (2014). 痴呆领域中的新概念:主观认知功能障碍. 国际神经病学神经外科学杂志, 41(1), 77-81.

Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C., … Rentz, D. M. (2012). Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia, 50(12), 2880-2886.

Blennow, K., & Hampel, H. (2003). CSF markers for incipient Alzheimer's disease. The Lancet Neurology, 2(10), 605-613.

Buerger, K., Ewers, M., Pirttilä, T., Zinkowski, R., Alafuzoff, I., Teipel, S. J., … Hampel, H. (2006). CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain, 129(11), 3035-3041.

Carr, D. B., Gray, S., Baty, J., & Morris, J. C. (2000). The value of informant versus individual's complaints of memory impairment in early dementia. Neurology, 55(11), 1724-1727.

de Leon, M. J., Convit, A., DeSanti, S., Golomb, J., Tarshish, C., Rusinek, H., … George, A. E. (1995). The hippocampus in aging and Alzheimer's disease. Neuroimaging Clinics of North America, 5(1), 1-17.

Edmonds, E. C., Delano-Wood, L., Galasko, D. R., Salmon, D. P., & Bondi, M. W. (2014). Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment. Journal of the International Neuropsychological Society, 20(8), 836-847.

Fyock, C. A., & Hampstead, B. M. (2015). Comparing the relationship between subjective memory complaints, objective memory performance, and medial temporal lobe volumes in patients with mild cognitive impairment. Alzheimer's & Dementia:Diagnosis, Assessment & Disease Monitoring, 1(2), 242-248.

Geerlings, M. I., Jonker, C., Bouter, L. M., Adèr, H. J., & Schmand, B. (1999). Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. American Journal of Psychiatry, 156(4), 531-537.

Grut, M., Jorm, A. F., Fratiglioni, L., Forsell, Y., Viitanen, M., & Winblad, B. (1993). Memory complaints of elderly people in a population survey:variation according to dementia stage and depression. Journal of the American Geriatrics Society, 41(12), 1295-1300.

Hill, N. L., Mogle, J., Wion, R., Munoz, E., DePasquale, N., Yevchak, A. M., & Parisi, J. M. (2016). Subjective cognitive impairment and affective symptoms:A Systematic Review. The Gerontologist, 56(6), e109-e127.

Jack, C. R., Jr., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., … Trojanowski, J. Q. (2010). Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. The Lancet Neurology, 9(1), 119-128.

Jack, C. R., Jr., Petersen, R. C., Xu, Y. C., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology, 52(7), 1397.

Jessen, F., Amariglio, R. E., van Boxtel M., Breteler, M., Ceccaldi, M., Chételat, G., … Wagner, M. (2014a). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's & Dementia, 10(6), 844-852.

Jessen, F., Feyen, L., Freymann, K., Tepest, R., Maier, W., Heun, R., … Scheef, L. (2006). Volume reduction of the entorhinal cortex in subjective memory impairment. Neurobiology of Aging, 27(12), 1751-1756.

Jessen, F., Wolfsgruber, S., Wiese, B., Bickel, H., Mösch, E., Kaduszkiewicz, H., … Wagner, M. (2014b). AD dementia risk in late MCI, in early MCI, and in subjective memory impairment. Alzheimer's & Dementia, 10(1), 76-83.

Lenehan, M. E., Klekociuk, S. Z., & Summers, M. J. (2012). Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI):Is it time to abandon subjective memory complaint as an MCI diagnostic criterion? International Psychogeriatrics, 24(9), 1505-1514.

Mitchell, A. J. (2008a). Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment? Age and Ageing, 37(5), 497-499.

Mitchell, A. J. (2008b). The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia:A meta-analysis. International Journal of Geriatric Psychiatry, 23(11), 1191-1202.

Molinuevo, J. L., Rabin, L. A., Amariglio, R., Buckley, R., Dubois, B., Ellis, K. A., … Jessen, F. (2017). Implementation of subjective cognitive decline criteria in research studies. Alzheimer's & Dementia, 13(3), 296-311.

Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001). Mild cognitive impairment represents early-stage Alzheimer disease. Archives of Neurology, 58(3), 397-405.

Mosconi, L., de Santi, S., Brys, M., Tsui, W. H., Pirraglia, E., Glodzik-Sobanska, L., … de Leon, M. J. (2008). Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints. Biological Psychiatry, 63(6), 609-618.

Polcher, A., Frommann, I., Koppara, A., Wolfsgruber, S., Jessen, F., & Wagner, M. (2017). Face-name associative recognition deficits in subjective cognitive decline and mild cognitive impairment. Journal of Alzheimer's Disease, 56(3), 1185-1196.

Reisberg, B., Ferris, S. H., de Leon, M. J., & Crook, T. (1982). The Global Deterioration Scale for assessment of primary degenerative dementia. The American journal of Psychiatry, 139(9), 1136-1139.

Reisberg, B., Prichep, L., Mosconi, L., John, E. R., Glodzik-Sobanska, L., Boksay, I., … de Leon, M. J. (2008). The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease. Alzheimer's & Dementia, 4(S1), S98-S108.

Reisberg, B., Shulman, M. B., Torossian, C., Leng, L., & Zhu, W. (2010). Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimer's & Dementia, 6(1), 11-24

Rentz, D. M., Parra Rodriguez, M. A., Amariglio, R, Stern, Y, Sperling, R, & Ferris, S. (2013). Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer's disease:A selective review. Alzheimer's Research & Therapy, 5(6),58.

Rodda, J., Dannhauser, T., Cutinha, D. J., Shergill, S. S., & Walker, Z. (2011). Subjective cognitive impairment:Functional MRI during a divided attention task. European Psychiatry, 26(7), 457-462.

Rodda, J. E., Dannhauser, T. M., Cutinha, D. J., Shergill, S. S., & Walker, Z. (2009). Subjective cognitive impairment:increased prefrontal cortex activation compared to controls during an encoding task. International Journal of Geriatric Psychiatry, 24(8), 865-874.

Rodda, J., Okello, A., Edison, P., Dannhauser, T., Brooks, D. J., & Walker, Z. (2010). 11C-PIB PET in subjective cognitive impairment. European Psychiatry, 25(2), 123-125.

Scheef, L., Spottke, A., Daerr, M., Joe, A., Striepens, N., Kölsch, H., … Jessen, F. (2012). Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology, 79(13), 1332-1339.

Schofield, P. W., Marder, K., Dooneief, G., Jacobs, D. M., Sano, M., & Stern, Y. (1997). Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. American Journal of Psychiatry, 154, 609-615.

Sinoff, G., & Werner, P. (2003). Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. International Journal of Geriatric Psychiatry, 18(10), 951-959.

Smart, C. M., & Krawitz, A. (2015). The impact of subjective cognitive decline on Iowa Gambling Task performance. Neuropsychology, 29(6), 971-987.

Stewart, R., Godin, O., Crivello, F., Maillard, P., Mazoyer, B., Tzourio, C., & Dufouil, C. (2011). Longitudinal neuroimaging correlates of subjective memory impairment:4-year prospective community study. The British Journal of Psychiatry, 198(3), 199-205.

Stomrud, E., Hansson, O., Blennow, K., Minthon, L., & Londos, E. (2007). Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly. Dementia and Geriatric Cognitive Disorders, 24, 118-124.

van der Flier, W. M., van Buchem, M. A., Weverling-Rijnsburger, A. W., Mutsaers, E. R., Bollen, E. L. E. M., Admiraal-Behloul, F., … Middelkoop, H. A. M. (2004). Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. Journal of Neurology, 251(6), 671-675.

van Harten, A. C., Visser, P. J., Pijnenburg, Y. A., Teunissen, C. E., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2013). Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints. Alzheimer's & Dementia, 9(5), 481-487.

van Oijen, M., de Jong, F. J., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2007). Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimer's & Dementia, 3(2), 92-97.

Wolfsgruber, S., Jessen, F., Koppara, A., Kleineidam, L., & Schmidtke, K., Frölich, L., … Wagner, M. (2015). Subjective cognitive decline is related to CSF biomarkers of AD in patients with MCI. Neurology, 84, 1261-1268.