DOI: 10.3724/SP.J.1095.2013.30375

Chinese Journal of Applied Chemistry (应用化学) 2013/30:12 PP.1386-1392

Photosensitizer Used in Clinical Photodynamic Thearpy for Cancer

Photodynamic therapy(PDT) has emerged as a selective and non-invasive modality for the treatment of malignant tumors. Photosensitizers are the key component of PDT, which generates cytotoxic reactive oxygen species(ROS) in the presence of oxygen and light with appropriate wavelength. In clinical practice, three families of photosensitizer(PS) are used, including porphyrins, chlorophylls and bacteriochloyin/phthalocyanines. This review focused on the oncologic photosensilizers that were in clinical uses or trials and from the points of view of successful photosensitizers explored the future trends of PS and PDT.

Key words:photodynamic therapy,photosensitizer,photosensitizer types,photosensitizer structure,photodynamic reaction

ReleaseDate:2015-06-08 13:47:11

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