doi:

DOI: 10.3724/SP.J.1095.2013.20590

Chinese Journal of Applied Chemistry (应用化学) 2013/30:12 PP.1438-1442

Microwave-Assisted Synthesis of 2-(4-Hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol via Potassium Hydroxide as the Catalyst


Abstract:
With the assistance of microwave, a mixture of 2-(4-hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol isomers were obtained via the condensation between hexafluoroacetone trihydrate(HFA·3H2O) and phenol using potassium hydroxide as catalyst. The product was characterized by 1H NMR, IR and MS spectra. The results show that the microwave-assisted process can reduce the reaction time remarkably compared with conventional processes. Under optimal conditions with the microwave power 300 W at n(phenol):n(HFA·3H2O):n(KOH)=3.0:1.0:0.3, the reaction time are shortened from 35 h in conventional heating to 6 h, the total yield is increased from 87% to 90% with 94% selectivity.

Key words:(hydroxy-phenyl)-hexafluoro-propan-ol,phenol,microwave,potassium hydroxide,hexafluoroacetone trihydrate,orthogonal experimental design

ReleaseDate:2015-06-08 13:48:00



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