DOI: 10.3724/SP.J.1264.2011.00002

Chinese Journal of Multiple Organ Diseases in the Elderly (中华老年多器官疾病杂志) 2011/10:4 PP.297-300

Function of islet β cells in non-diabetic population with hyperinsulinemia

Objective To analyze the function of islet β cells in population who had normal glucose tolerance (NGT) or impaired glucose regulation (IGR) with hyperinsulinemia(HINS). Methods A total of 634 adults diagnosed as NGT or IGR with HINS by 75g oral glucose tolerance test(OGTT) were included for the analysis of the islet β cells function. Results In HINS group, homeostasis model insulin resistance index(HOMA-IR), DI120/DG120, the first and second phase insulin secretion index were significantly higher than those in non-HINS group of non-diabetic population(P<0.05=, but insulin sensitive index(ISI)-Stumvoll and HOMA beta cells function index/insulin resistance(HBCI/IR) were significantly lower(P<0.05=. There was no significant difference in DI120/DG120/IR between the two groups(P>0.05). In IGR with HINS group, HBCI, HBCI/IR, and the first and second phase insulin secretion index were significantly lower than those in NGT with HINS group(P<0.05=. There was no significant difference in HOMA-IR and ISI-Stumvoll between the two groups(P>0.05). Conclusions Although the absolute insulin secretion is increasing in the NGT or IGR population with HINS, the islet b cells function decreases gradually. NGT or IGR with HINS are the transition state in the progress of diabetes mellitus, and the early detection and interference are strongly recommended.

Key words:hyperinsulinemia,insulin resistance,islet b cell function

ReleaseDate:2014-07-21 15:56:13

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