doi:

DOI: 10.3724/SP.J.1264.2011.00002

Chinese Journal of Multiple Organ Diseases in the Elderly (中华老年多器官疾病杂志) 2011/10:4 PP.297-300

Function of islet β cells in non-diabetic population with hyperinsulinemia


Abstract:
Objective To analyze the function of islet β cells in population who had normal glucose tolerance (NGT) or impaired glucose regulation (IGR) with hyperinsulinemia(HINS). Methods A total of 634 adults diagnosed as NGT or IGR with HINS by 75g oral glucose tolerance test(OGTT) were included for the analysis of the islet β cells function. Results In HINS group, homeostasis model insulin resistance index(HOMA-IR), DI120/DG120, the first and second phase insulin secretion index were significantly higher than those in non-HINS group of non-diabetic population(P<0.05=, but insulin sensitive index(ISI)-Stumvoll and HOMA beta cells function index/insulin resistance(HBCI/IR) were significantly lower(P<0.05=. There was no significant difference in DI120/DG120/IR between the two groups(P>0.05). In IGR with HINS group, HBCI, HBCI/IR, and the first and second phase insulin secretion index were significantly lower than those in NGT with HINS group(P<0.05=. There was no significant difference in HOMA-IR and ISI-Stumvoll between the two groups(P>0.05). Conclusions Although the absolute insulin secretion is increasing in the NGT or IGR population with HINS, the islet b cells function decreases gradually. NGT or IGR with HINS are the transition state in the progress of diabetes mellitus, and the early detection and interference are strongly recommended.

Key words:hyperinsulinemia,insulin resistance,islet b cell function

ReleaseDate:2014-07-21 15:56:13



[1] 邓尚平. 胰岛素抵抗的临床测定方法和评价[A]//李秀均. 代谢综合征(胰岛素抵抗综合征)[M]. 第2版. 北京: 人民卫生出版社, 2007: 93

[2] World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus. Geneva, 1999.

[3] Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia, 1985, 28(7): 412-419.

[4] Stumvoll M, Van Haeften T, Fritsche A, et al. Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times[J]. Diabetes Care, 2001, 24(4): 796-797.

[5] Haffner SM, Kennedy E, Gonzalez C, et al. A prospective analysis of the HOMA model. The Mexico City Diabetes Study[J]. Diabetes Care, 1996, 19(10): 1138-1141.

[6] Shanik MH, Xu Y, Skrha J, et al. Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse[J]? Diabetes Care, 2008, 31(suppl 2): S262-S268.

[7] Burchfiel CM, Sharp DS, Curb JD, et al. Hyperinsulinemia and cardiovascular disease in elderly men: the Honolulu Heart Program[J]. Arterioscler Thromb Vasc Biol, 1998, 18(3): 450-457.

[8] Weyer C, Hanson RL, Tataranni PA, et al. A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia[J]. Diabetes, 2000, 49(12): 2094-2101.

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