doi:

DOI: 10.3724/SP.J.1264.2011.00003

Chinese Journal of Multiple Organ Diseases in the Elderly (中华老年多器官疾病杂志) 2011/10:4 PP.301-304

Relationship of prolonged QTc interval and multi-cardiovascular risk factors in patients with type 2 diabetes mellitus


Abstract:
Objective To investigate the relationship between the prolonged QTc interval and the multi-cardiovascular risk factors in patients with type 2 diabetes mellitus(T2DM). Methods Medical data of 3940 T2DM patients were analyzed. After patients who had coronary heart diseases, arrhythmia, myocardial infarction, which may cause abnormal QTc, were excluded, a total of 3426 T2DM patients who had underwent diabetic complication assessment and 12 standard electrocardiogram(ECG) recording were enrolled. They were divided into normal QTc interval group(QTc<0.44 s, n = 2157= and prolonged QTc interval group(QTc≥0.44s, n = 1269). The multi-cardiovascular risk factors were compared between the two groups and further analyzed. Results Compared with normal QTc interval group, the patients in prolonged QTc interval group were older[(55.6±11.0) vs (54.6±10.9) years], had longer diabetes duration[36(12, 96) vs 36(6, 84)months, median(P25, P75)], more females (51.5% vs 41.5%), shorter body height[ (1.64±0.08) vs (1.65±0.08) m], bigger body mass index(BMI)[(26.2±3.6) vs (25.8±3.2) kg/m2], bigger waist circumference[(89.7±9.6) vs (88.2±9.5) cm], bigger hip circumference[(95.4±7.3) vs (94.4±6.6)cm], higher waist hip ratio(WHR)[(0.94±0.07) vs (0.93±0.08)], higher blood pressure [(134.8±20.3) /(76.9±10.2) vs (130.1±19.1) /(74.5±9.6) mmHg], increased heart rate [(82.9±10.2) vs (70.7±10.1)beats/min], higher HbA1c [(8.0±2.0)% vs (7.7±1.9)%], higher post-meal glucose[(13.7±5.1) vs (12.8±4.8) mmol/L], higher fasting insulin[(9.4±8.6) vs (8.2±7.5)IU/ml], increased total cholesterol[(5.1±1.1) vs (5.0±1.1) mmol/L], higher triglyceride [(2.4±2.6) vs (2.2±2.5) mmol/L], and higher urine albumin/creatinine(Alb/Cr)[15(8, 36) vs 12 (7, 27) mg/g, median(P25, P75)]. All these indices were significantly different between the two groups(P<0.05). Logistic regression analysis showed that factors including age, sex, BMI, waist circumference, WHR, heart rate and Cr, were significantly associated with prolonged QTc interval. Conclusions More than one third of T2DM patients present with prolonged QTc interval and more severe multi-cardiovascular risk factors.

Key words:diabetes mellitus, type 2,QTc,cardiovascular diseases,risk factors

ReleaseDate:2014-07-21 15:56:14



[1] Pappone C, Santinelli V. Cardiac electrophysiology in diabetes[J]. Minerva Cardioangiol, 2010, 58(2): 269-276.

[2] 钱荣立. 关于糖尿病的新诊断标准与分型[J]. 中国糖尿病杂志, 2000, 8(1): 5-6.

[3] 郭继鸿. 心电图学[M]. 北京: 人民卫生出版社, 2002: 132-134.

[4] 王福军, 周晓英, 向芝青, 等. Q-T间期与Q-T间期异常[J]. 实用心电学杂志, 2004, 13(4): 319-320.

[5] Lykke JA, Tarnow L, Parving HH, et al. A combined abnormality in heart rate variation and QT corrected interval is a strong predictor of cardiovascular death in type 1 diabetes[J]. Scand J Clin Lab Invest, 2008: 68(7): 654-659.

[6] Veglio M, Giunti S, Stevens LK, et al. Prevalence of Q-T interval dispersion in type 1 diabetes and its relation with cardiac ischemia: the EURODIAB IDDM Complications Study Group[J]. Diabetes Care, 2002, 25(4): 702-707.

[7] Veglio M, Bruno G, Borra M, et al. Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population-based cohort[J]. J Inter Med, 2002, 251(4): 317-324.

[8] Pourmoghaddas A, Hekmatnia A. The relationship between QTc interval and cardiac autonomic neuropathy in diabetes mellitus[J]. Mol Cell Biochem. 2003, 249(1-2): 125-128.

[9] Xu ZR, Molyneaux L, Wang YZ, et al. Clustering of cardiovascular risk factors with diabetes in Chinese patients: the effects of sex and hyperinsulinaemia diabetes[J]. Diabetes Obes Metab, 2001, 3(3): 157-162.

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