doi:

DOI: 10.3724/SP.J.1264.2011.00020

Chinese Journal of Multiple Organ Diseases in the Elderly (中华老年多器官疾病杂志) 2011/10:4 PP.370-373

RASAL1 expression and ras activity with gastrointestinal tumors: a review


Abstract:
Approximately 20% of human tumors are associated with mutations of ras genes. Ras proteins control cellular signaling pathways responsible for cell proliferation, differentiation, survival and apoptosis. Ras proteins belong to the large family of small GTPases, which are activated in response to various extracellular stimuli. RASAL1, as a ras GTPase activating protein, inhibits ras acti-vation. Regulation of ras and RASAL1 activities may lead the direction of target treatment of tumors. Detection of ras and RASAL1 activities can provide more relevant information about diagnosis and prognosis of gastrointestinal tumors. In this paper, we reviewed the structure, the biochemical properties of ras proteins, and the role of its mutations in tumors. We further discussed the inhibitive effects of RASAL1 on ras activities. Finally, we commented the correlation of ras and RASAL1 with gastrointestinal tumors.

Key words:RASAL1,ras, gene,tumor,diagnosis,prognosis

ReleaseDate:2014-07-21 15:56:26



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