DOI: 10.3724/SP.J.1009.2013.00588

Chinese Journal of Natural Medicines (中国天然药物) 2013/11:6 PP.588-595

Progress on the protective effect of compounds from natural medicines on cerebral ischemia

The treatment of cerebral ischemic disease by natural medicines has a long history, and has accumulated a rich theoretical knowledge and treatment experience. The objective of this review is to critically evaluate the experimental research situation of the protective effect of the individual compounds from natural medicine on cerebral ischemia in the past ten years, emphasizing the major mechanisms underlying cerebral ischemic pathophysiology. Sixteen representative compounds from natural medicines which are often used to treat stroke are discussed. The results indicate that these components possess a protective effect on cerebral ischemia, and that these components have different mechanisms, including inhibiting excitotoxicity by ginkgolide B, antiapoptosis of breviscapine, influencing astrocytic activation and proliferation of tanshinone IIA, influencing free radicals by ginsenoside Rd, impairing blood-brain barrier disruption by baicalin, and the anti-inflammatory activity of tetramethylpyrazine. Moreover, some components have multiple neuroprotective mechanisms. Therefore, the combination of individual compounds from natural medicines, considering the mechanisms of cerebral ischemia, may be beneficial to patients with cerebral ischemia in the future. This approach will provide a direction for the further application and exploitation of new drug development in the treatment of cerebral ischemia.

Key words:Natural medicine,Individual compounds,Cerebral ischemia,Pathophysiological mechanisms,Research progress

ReleaseDate:2014-07-21 17:04:18

Funds:Science and Technology Research Project of Chongqing (No. CSTC2010AC5011), Ministry of Education Doctoral Program spe-cial fund (No. 20110182110012) and the Key Projects of Chinese Medicine Research of Chongqing Municipal Health Bureau (2010[60] 2010-1-4)