doi:

DOI: 10.3724/SP.J.1009.2008.00387

Chinese Journal of Natural Medicines (中国天然药物) 2008/6:5 PP.387-390

Metabolites of Echinacoside in Rats Feces by HPLC-MSn


Abstract:
AIM: To investigate the metabolites of echinacoside in rat feces. METHODS: The feces were collected after oral administration of 100 mgkg1 echinacoside to rats. The samples were detected by LC-MSn . RESULT: The major metabolites were found in rat feces and their chemical structures were identified primarily. CONCLUSION: The metabolites found in feces are acteoside, decaffeoylacteoside, lugrandoside, 3, 4-dihydroxyphenylethanol.

Key words:Echinacoside,Feces,Metabolites,HPLC-MSn

ReleaseDate:2014-07-21 14:28:20



[1]Deng M, Zhao JY, Tu PF, et al. Echinacoside rescues the SHSY5Y neuronal cells from TNFα-induced apoptosis [J]. Eur J Pharmacol, 2004, 505: 11-18.

[2]Speroni E, Govoni P, Guizzardi S, et al. Anti-inflammatory and cicatrizing activity of Echinacea pallida Nutt. root extract [J]. J Ethnopharmacol, 2002, 79: 265–272.

[3]Yoshikawa M, Matsuda H, Morikawa T, et al. Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa [J]. Bioorgan Med Chem, 2006, 14: 7468–7475.

[4]Wu Y, Li L, Wen T, et al. Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats [J]. Toxicol, 2007, 232: 50–56.

[5]Jia CQ, Shi HM, Wu XM, et al. Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability [J]. J Chromatogr B, 2006, 844: 308–313.

[6]雷 厉(Lei L), 宋志宏(Song ZH), 李寅增(Li YZ), 等. 管花肉苁蓉苯乙醇总苷在狗胃肠道内的生物转化[J]. 药学学报(Acta Pharm Sin), 2001, 36 (6): 432-435.

PDF