DOI: 10.3724/SP.J.1009.2009.00145

Chinese Journal of Natural Medicines (中国天然药物) 2009/7:2 PP.145-149

Bioinformatic Analysis on Jellyfish Hematoxin

AIM: To illustrate the structure and function of five hematoxin sequences reported in four jellyfish and explore the possible mechanism of pathogenesis. METHODS: Bioinformatic methods were used to analyze the composition and sequence of amino acid residues, physico-chemical property, signal peptide, membrane spanning domain, hydrophobicity or hydrophilicity, secondary structure, conserved region and molecular phylogenetic evolution. RESULT and CONCLUSIONS: The results showed that the five jellyfish hematoxins were similar in composition and sequence of amino acid residues and physico-chemical property. The amino acid sequences of jellyfish hematoxins contained membrane spanning domain and hydrophobic regions; with a possible cleavage site in the signal peptide between the amino acid residues 20 and 21; α-helix and random coil were the major motifs of predicted secon-dary structure while β-turn and extended strand spread in the whole protein; There were four conserved amino acid sequences in three of the five hematoxins and similar phylogenetic trees were constructed by both NJ and MP methods.

Key words:Jellyfish,Hematoxin,Bioinformatics

ReleaseDate:2014-07-21 14:37:27

Funds:This project was supported by the Natural Science Foundation of Shanghai Municipal Government (No. 06ZR14111) and “Eleventh Five-Year Plan” for Medical Science Development of PLA (No. 06Z020).

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