doi:

DOI: 10.3724/SP.J.1005.2014.00095

Hereditas (Beijing) (遗传) 2014/36:2 PP.95-102

Crosstalk of Hippo/YAP and Wnt/β-catenin pathways


Abstract:
Wnt/β-catenin and Hippo/YAP pathways are known to be important for development, growth, organogenesis, and maintenance of adult stem cells. In mammalian cells, Wnt signalling stabilises cytoplasmic β-catenin through several core molecules to promote β-catenin to enter the nucleus, thus delivers the growth -promoting signal. Hippo kinase cascade pathway promotes cytoplasmic localization of YAP/TAZ, which restricts cell proliferation and induces apoptosis. Deregula-tion of these two pathways could lead to tumorigenesis. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Elucidating the regulatory mechanism and biological functions of Hippo/YAP and Wnt/β-catenin pathways might reveal potential targets for tumor therapeutic intervention. In this review, we discuss on the interactions between Wnt/β-catenin and Hippo/YAP pathways, and how these interactions contribute to tumorigenesis.

Key words:Hippo/YAP pathway,Wnt/β-catenin pathway,interaction,cancer

ReleaseDate:2014-07-21 17:05:49