DOI: 10.3724/SP.J.1005.2009.00683

Hereditas (Beijing) (遗传) 2009/31:7 PP.683-688

In vivo delivery of siRNA

RNA interference (RNAi) is a mechanism of posttranscriptional gene silencing mediated by small interfering RNA (siRNA). The ability of synthetic siRNA to silence genes in vivo has made it well suited as therapeutic drug, but the instability and polarity of siRNA and the complexity of in vivo circumstances retarded rapid development of RNAi-based therapies. In this review, a summary of the advances on in vivo siRNA delivery is presented and dis-cussed.

Key words:RNAi,siRNA,siRNA delivery

ReleaseDate:2014-07-21 14:39:25

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