doi:

DOI: 10.3724/SP.J.1249.2017.03313

Journal of Shenzhen University Science and Engineering (深圳大学学报理工版) 2017/34:3 PP.313-318

Thermal stability and biotoxicity of PES-HA biocomposites


Abstract:
Polyethersulfone-hydroxyapatite (PES-HA) biocomposites were prepared by dissolving ultrasonic method. Infrared spectroscopy shows that the composites are mainly composed by physical bonding. The thermo gravimetric analysis indicates that the thermal stability of the composites increases with the increase of HA content and the thermal decomposition reaction order is about 1. Cytotoxicity test shows that the toxicity level of the material is gradeⅠ, and the composites have no toxicity to MG-63 cells. The addition of HA into PES results in a relative increase in the growth rate of cells for the composites, thus improving the cell biocompatibility. The cells grow well in the material extract, the adherent cells are spindle or polygonal, with strong refraction and obvious cell proliferation.

Key words:biological materials,composite materials,polyether sulfone,hydroxyapatite,thermal stability,decomposition kinetics,cytotoxicity

ReleaseDate:2017-06-16 14:08:45



[1] Maria C R, Alessia B, Michele L, et al. Thermal and mechanical properties of PES/PTFE composites and nancomposites[J]. Science,2013,130(5):3624-3633.

[2] Cao Jinshan, Cheng Zhiqiang, Kang Lijuan, et al. Novel anti-fouling polyethersulfone/polyamide 66 membrane preparation for air filtration by electro spinning[J]. Electronic Materials Letters,2017,192(26):12-16.

[3] Zhang Xiguang, Wang Huaiyuan, Liu Zhanjian, et al. Fabrication of durable fluorine-free super hydrophobic polyethersulfone (PES) composite coating enhanced by assembled MMT-SiO2 nanoparticles[J]. Applied Surface Science,2017,396(27):1580-1588.

[4] Salgado A J, Oliveira J M, Martins A,et al.Tissue engineering and regenerative medicine: past, present, and future[J]. International Review of Neurobiology,2013,108(8):1-33.

[5] 倪 卓,黄苇殷,王 应,等.PEEK-SPEEK-HA复合材料与U2OS细胞相容性研究[J].深圳大学学报理工版,2016,33(1):1-9. Ni Zhuo, Huang Weiyin, Wang Ying, et al. Experiments on biocompatibility of PEEK-SPEEK-HA composite materials with U2OS cells[J]. Journal of Shenzhen University Science and Engineering, 2016,33(1):1-9.(in Chinese)

[6] 倪 卓, 刘士德,王 应,等.PEEK-HA生物复合材料对成纤维细胞3T3的影响[J]. 深圳大学学报理工版,2013, 30(4):392-397. Ni Zhuo, Liu Shide, Wang Ying, et al. Influence of 3T3 cells for PEEK-HA composite[J]. Journal of Shenzhen University Science and Engineering, 2013, 30(4):392-397.(in Chinese)

[7] Li Bo, Liao Xiaoling, Zheng Li, et al. Preparation and cellular response of porous A-type carbonated hydroxyapatite nanoceramics[J]. Materials Science and Engineering C-Materials for Biological Applications,2012,32:929-936.

[8] Zhou Keqing, Gao Rui, Jiang Saihua, et al. Morphology thermal and mechanical properties of poly(epsilon-caprolactone) biocomposites reinforced with nan-hudroyapatite decorated grapheme[J]. Journal of Colloid and Interface Science,2017,496(78): 334-342.

[8] GB/T1447—2005 纤维增强塑料拉伸性能试验方法[S]. GB/T1447—2005 Test method for tensile properties of fiber reinforced plastics[S].(in Chinese)

[10] 胡荣祖,高胜利,张建军,等.热分析动力学[M].北京:科学出版社,2008: 79-80. Hu Rongzu, Gao Shengli, Zhang Jiangjun, et al. Thermal analysis kinetics[M]. Beijing: Science Press, 2008: 79-80.(in Chinese)

[11] Chandrasekaran A, Ramachandran S, Subbiah S, et al. Determination of kinetic parameters in the pyrolysis operation and thermal behavior of juliflora using thermogravimetry analysis[J]. Bioresource Technology,2017,233(21):413-422.

[12] Fiocco L, Li L, Stevens M M, et al. Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics[J]. Acta Biomaterialia, 2016, 50(4): 56-67.

[13] Yu Yadong, Zhua Yingjie, Qi Chao, et al. Hydroxyapatite nanorod-assembled porous hollow polyhedral as drug/protein carriers[J]. Journal of Colloid and Interface Science,2017,496(15):416-424.

[14] Arahira T, Maruta M, Matsuya S, et al. Characterization and in vitro evaluation of biphasic alpha-tricalcium phosphate/beta-tricalcium phosphate cement[J]. Materials Science & Engineering Materials for Biological Applications, 2016,74(7): 478-484.

[15] Du J, Tan E, Kim H J, Zhang A, et al. Comparative evaluation of chitosan, cellulose acetate, and polyethersulfone nanofiber scaffolds for neural differentiation[J]. Carbohydrate Polymers,2014,99(15):483-490.

[16] 倪 卓,王 应,王 双,等.PEEK-HA生物复合材料对MG-63细胞的作用[J]. 深圳大学学报理工版,2014,31(3):258-265. Ni Zhuo,Wang Ying,Wang Shuang,et al. Influence of PEEK/HA composites on MG-63 cells[J]. Journal of Shenzhen University Science and Engineering, 2014,31(3):258-265.(in Chinese).

[17] Vimalrai S, Arumugam B, Miranda J P, et al. Run2: structure function and phosphorylation in osteoblast differentia[J]. International Journal of Biological Macromolecules, 2015, 78(18): 202-208.

[18] Akihiro N, Masaki A, Fumi T Y, et al. Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes[J]. Journal of Pharmacological Sciences, 2016,133(1):18-24.