DOI: 10.3724/SP.J.1206.2012.00535

Progress in Biochemistry and Biophysics (生物化学与生物物理进展) 2013/40:12 PP.1186-1192

Research Advances in Natural Regulatory T Cell Development and Differentiation

CD4+CD25+ regulatory T cells (Treg cells) play crucial roles in the maintenance of self-immunetolerance. Decreased numbers or functional deficiency of Treg cells result in development of a variety ofautoimmune diseases like multiple sclerosis and type Ⅰ diabetes. Moreover, Treg cells have been implicated ininflammation and transplantation settings. Two types of Treg cells including thymic-derived natural Treg (nTreg)and peripheral induced Treg (iTreg) cells have been identified based on their distinct developmental origin. nTregcells are derived in the thymus and express high level of Forkhead transcription factor Foxp3, nTreg cells exhibitthe suppressive function mainly in a cell-cell contact manner. nTreg cells develop in two steps largely shaped byTCR, co-stimulatory and cytokines in the thymus. In the present manuscript, we will mainly summarize recentadvances regarding molecular and cellular regulation of nTreg development and differentiation.

Key words:nTreg,Foxp3,CD25,thymus,immune tolerance

ReleaseDate:2015-04-18 09:14:49

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