DOI: 10.3724/SP.J.1206.2009.00474

Progress in Biochemistry and Biophysics (生物化学与生物物理进展) 2010/37:2 PP.138-144

Progress of Differentiating Human Embryonic Stem Cells Into Endothelial Progenitor Cells and Potential Applications*

Endothelial progenitor cells have great prospect for treatment of many diseases. However, derivation of endothelial progenitor cells in vitro is a major restriction for the clinical treatment. Human embryonic stem cells (hESCs) may become an alternative source of endothelial progenitor cells because of their high proliferation capability and in vitro pluripotency. Although, there are many challenges for differentiating hESCs to endothelial progenitor cells in vitro. Current understanding of this subject from recent discoveries in this field was summarized. Future work will be needed to translate these in vitro findings to clinical applications.

Key words:human embryonic stem cells, endothelial progenitor cells, differentiation, clinical applications

ReleaseDate:2014-07-21 15:11:50

Funds:This work was supported by grants from Hi-Tech Research and Development Program of China (2006AA02A107) and The Project of Beijing Municipal Science & Technology Commission(D07050701350702)

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