DOI: 10.3724/SP.J.1141.2013.02103

Zoological Research (动物学研究) 2013/34:2 PP.103-107

A DTI study of the contralateral corticospinal tract modeled through simulated intracranial space-occupying lesions in macaque brain motor areas

Recent studies found that a loss of motor function following corticospinal tract (CST) damage can, to some extent, be restored. Few studies, however, examine how space-occupying lesions in the brain motor area may affect the contralateral CTS structure and function. We performed a simulation of intracranial space-occupying lesions in the brain motor area by implanting of balloons into the brains of the two healthy macaques. Diffusion tensor imaging (DTI) was performed on the macaques’ brains four times to measure the FA values of the contralateral CST operative area. The results showed that on the day of balloon implantation, the FA values had no obvious effect, but with time the effect increased, becoming increasingly apparent one week after removing the balloons. Experimental results demonstrated that this model was both feasible and reliable. After the simulated space-occupying lesions occurred in the brain motor area, DTI showed a compensatory response of the contralateral CTS, which remained for a short period of time even after the lesions were removed. This result suggests that the contralateral CST may then also contribute to recovery of limb function.

Key words:Macaque,Simulation model of intracranial space-occupying lesions,Corticospinal tract,Diffusion tensor imaging

ReleaseDate:2015-04-16 19:34:18

Barrick TR, Clark CA. 2004. Singularities in diffusion tensor fields and their relevance in white matter fiber tractography. Neuroimage, 22(2): 481-491.

Beaulieu C, Allen PS. 1994. Water diffusion in the giant axon of the squid: implications for diffusion weighted MRI of the nervous system. Magnetic Resonance in Medicine, 32(5): 579-583.

Chenevert TI, Brunberg JA, Pipe JG. 1990. Anisotropic diffusion within human white matter: demonstration with NMR techniques in vivo. Radiology, 177(2): 401-405.

Dong Y. 2006. Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke. Stroke, 37(6): 1552-1555.

Eriksson SH, Rugg-Gunn FJ, Symms MR, Barker GJ, Duncan JS. 2001. Diffusion tensor imaging in patients with epilepsy and malformations of cortical development. Brain, 124(Pt 3): 617-626.

Fenrich KK, Skelton N, MacDermid VE, Meehan CF, Armstrong S, Neuber-Hess MS, Rose PK. 2007. Axonal regeneration and development of de novo axons from distal dendrites of adult feline commissural interneurons after a proximal axotomy. Journal of Comparative Neurology, 502(6): 1079-1097.

Jellison BJ, Field AS, Medow J, Lazar M, Salamat MS, Alexander AL. 2004. Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. American Journal of Neuroradiology, 25(3): 356-369.

Klose U, Mader I, Unrath A, Erb M, Grodd W. 2004. Directional correlation in white matter tracks of the human brain. Journal of Magnetic Resonance Imaging, 20(1): 25-30.

Kuai XL, Gagliardi C, Flaat M, Bunnell BA. 2009. Differentiation of nonhuman primate embryonic stem cells along neural lineages. Differentiation, 77(3): 229-238.

Le Bihan D. 2003. Looking into the functional architecture of the brain with diffusion MRI. Nature Reviews Neuroscience, 4(6): 469-480.

Liao CH, Su B. 2012. Research proceedings on primate comparative genomics. Zoological Research, 33(1): 108-118. [廖承红, 宿兵. 2012. 灵长类比较基因组学的研究进展. 动物学研究, 33(1): 108-118.]

Meintzschel F, Ziemann U. 2006. Modification of practice-dependent plasticity in human motor cortex by neuromodulators. Cerebral Cortex, 16(8): 1106-1115.

Rao XP, Xu ZX, Xu FQ. 2012. Progress in activity-dependent structural plasticity of neural circuits in cortex. Zoological Research, 33(5): 527-536. [饶小平, 许智祥, 徐富强. 2012. 大脑皮层内活动依赖的神经环路结构可塑性研究进展. 动物学研究, 33(5): 527-536.]

Susan S. 2005. Gray`s Anatomy: The Anatomical Basis of Clinical Practice, 39/E. London: Elsevier, 458-562.

Tang XY, Xia LM, Zhu WZ. 2012. DTI study off relationship between infarction damage as well as Wallerian degeneration of CTS and motor function following chronic cerebral infarction. Radiologic Practice, 27(5): 484-488. [汤翔宇, 夏黎明, 朱文珍. 2012. 慢性期脑梗死患者脑梗死灶扩散变化及Wallerian变性与运动功能关系DTI研究. 放射学实践, 27(5): 484-488.]

Teasdale G, Jennett B. 1974. Assessment of coma and impaired consciousness. A practical scale. Lancet, 2(7872): 81-84.

Yeo SS, Choi BY, Chang CH, Jang SH. 2010. Transpontine connection fibers between corticospinal tracts in hemiparetic patients with intracerebral hemorrhage. European Neurology, 63(3): 154-158.

Yu CS, Zhu CZ, Zhang YJ, Chen H, Qin W, Wang ML, Li KC. 2009. A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke. Neuroimage, 47(2): 451-458.