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DOI: 10.3724/SP.J.1260.2011.00272

ACTA BIOPHYSICA SINICA 2011/27 :4 PP.272-288

Mini Review

Magnetic Iron Oxide Nanoparticles and Their Applications in Magnetic Resonance Imaging

QIAO Ruirui , JIA Qiaojuan , ZENG Jianfeng , GAO Mingyuan

Institute of Chemistry, the Chinese Academy of Sciences, Beijing, 100190, China

Abstract: Magnetic iron oxide nanoparticles have received great attention due to their applications as contrast agents for magnetic resonance imaging (MRI). Now, in vivo applications of iron oxide nanoparticles are gradually shifting from passive targeting mode, such as liver imaging, to active targeting mode, leading to the emerging of a new multidisciplinary field-Molecular Imaging. This review mainly discusses the synthesis of magnetic iron oxide nanoparticles and their MRI applications, especially in molecular imaging of early tumors.

Keywords: Magnetic iron oxide nanoparticles  Magnetic resonance  Molecular imaging probe  Tumor 

Recieved: 2010-11-26 ; Accepted: 2011-02-18; Published Online: 2011-07-18

Corresponding Author: GAO Mingyuan (gaomy@iccas.ac.cn)

Supported By:"973" Program (2011CB935800), the National Natural Science Foundation of China (21003135, 81090271, 20820102035)