Positive rate of PF4/H antibody, its risk factors and association with thrombosis in maintenance hemodialysis patients
Department of Nephrology, General Hospital of PLA, State Key Laboratory of Kidney Disease,
Objective To study the positive rate of PF4/H antibodies in maintenance hemodialysis patients, and to analyze its risk factor and association with thrombosis. Methods A total of 157 maintenance hemodialysis patients were recruited in the present study. A cross-sectional and a longitude study were designed, and statistical analysis was used to analyze the risk factors of PF4/H antibody level and its association with thrombosis event. Results We found that 40.8%(64/157) of the patients were positive for PF4/H antibody. Past-thrombosis events, heparin types, duration and weekly dialysis hours were significantly different between antibody-positive group and antibody-negative group(P<0.05). Incidence of thrombosis event in antibody-positive group was significantly lower than that in the antibody-negative group(P<0.05). The risk ratio of antibody positivity for thrombosis event was 2.349. The incidence of thrombotic event in antibody-positive patients who took anti-platelet agents was lower than that in those who did not take. Conclusion The positive rate of PF4/H antibody has been found to be 40.8% in the present group. Thrombosis events, heparin types, duration and weekly dialysis hours are the risk factors of PF4/H antibody level. PF4/H antibody can serve as a marker for thrombotic events, and anti-platelet agents are effective for preventing from thrombotic events in PF4/H antibody positive patients.